RAS-targeted therapies: is the undruggable drugged?
AR Moore, SC Rosenberg, F McCormick… - Nature reviews Drug …, 2020 - nature.com
Abstract RAS (KRAS, NRAS and HRAS) is the most frequently mutated gene family in
cancers, and, consequently, investigators have sought an effective RAS inhibitor for more …
cancers, and, consequently, investigators have sought an effective RAS inhibitor for more …
Neoadjuvant immunotherapy with nivolumab and ipilimumab induces major pathological responses in patients with head and neck squamous cell carcinoma
JL Vos, JBW Elbers, O Krijgsman, JJH Traets… - Nature …, 2021 - nature.com
Surgery for locoregionally advanced head and neck squamous cell carcinoma (HNSCC)
results in 30‒50% five-year overall survival. In IMCISION (NCT03003637), a non …
results in 30‒50% five-year overall survival. In IMCISION (NCT03003637), a non …
The impact of site-specific digital histology signatures on deep learning model accuracy and bias
Abstract The Cancer Genome Atlas (TCGA) is one of the largest biorepositories of digital
histology. Deep learning (DL) models have been trained on TCGA to predict numerous …
histology. Deep learning (DL) models have been trained on TCGA to predict numerous …
Tumor microenvironment and immune evasion in head and neck squamous cell carcinoma
A Elmusrati, J Wang, CY Wang - International journal of oral science, 2021 - nature.com
Head and neck squamous cell carcinoma (HNSCC), an aggressive malignancy, is
characterized by high morbidity and low survival rates with limited therapeutic options …
characterized by high morbidity and low survival rates with limited therapeutic options …
Futibatinib, an Irreversible FGFR1–4 Inhibitor, in Patients with Advanced Solid Tumors Harboring FGF/FGFR Aberrations: A Phase I Dose-Expansion Study
F Meric-Bernstam, R Bahleda, C Hierro, M Sanson… - Cancer discovery, 2022 - AACR
Futibatinib, a highly selective, irreversible FGFR1–4 inhibitor, was evaluated in a large
multihistology phase I dose-expansion trial that enrolled 197 patients with advanced solid …
multihistology phase I dose-expansion trial that enrolled 197 patients with advanced solid …
Role of PI3K/AKT pathway in cancer: the framework of malignant behavior
N Jiang, Q Dai, X Su, J Fu, X Feng, J Peng - Molecular biology reports, 2020 - Springer
Given that the PI3K/AKT pathway has manifested its compelling influence on multiple
cellular process, we further review the roles of hyperactivation of PI3K/AKT pathway in …
cellular process, we further review the roles of hyperactivation of PI3K/AKT pathway in …
Pan-cancer image-based detection of clinically actionable genetic alterations
Molecular alterations in cancer can cause phenotypic changes in tumor cells and their
microenvironment. Routine histopathology tissue slides, which are ubiquitously available …
microenvironment. Routine histopathology tissue slides, which are ubiquitously available …
Clinical update on head and neck cancer: molecular biology and ongoing challenges
Head and neck squamous cell carcinomas (HNSCCs) are an aggressive, genetically
complex and difficult to treat group of cancers. In lieu of truly effective targeted therapies …
complex and difficult to treat group of cancers. In lieu of truly effective targeted therapies …
The changing therapeutic landscape of head and neck cancer
Head and neck cancers are a heterogeneous collection of malignancies of the upper
aerodigestive tract, salivary glands and thyroid. In this Review, we primarily focus on the …
aerodigestive tract, salivary glands and thyroid. In this Review, we primarily focus on the …
Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma
Nasopharyngeal carcinoma (NPC) is an aggressive malignancy with extremely skewed
ethnic and geographic distributions. Increasing evidence indicates that targeting the tumor …
ethnic and geographic distributions. Increasing evidence indicates that targeting the tumor …