Human papillomavirus (HPV) is a small double-stranded DNA virus that commonly infects
humans. The oncogenic characteristics of HPV derive from the oncoproteins E6 and E7 that …

PURPOSE Mutations in the HRAS (m HRAS) proto-oncogene occur in 4%-8% of patients
with recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) …

Cancers display significant heterogeneity with respect to tissue of origin, driver mutations,
and other features of the surrounding tissue. It is likely that individual tumors engage …

Background Patients with recurrent or metastatic squamous cell carcinoma of the head and
neck have few treatment options. We aimed to assess the safety, tolerability, and antitumour …

There is great potential for genome sequencing to enhance patient care through improved
diagnostic sensitivity and more precise therapeutic targeting. To maximize this potential …

Anti-tumor immunity is driven by self versus non-self discrimination. Many
immunotherapeutic approaches to cancer have taken advantage of tumor neoantigens …

About half of all cancers have somatic integrations of retrotransposons. Here, to characterize
their role in oncogenesis, we analyzed the patterns and mechanisms of somatic …

To compare lung adenocarcinoma (ADC) and lung squamous cell carcinoma (SqCC) and to
identify new drivers of lung carcinogenesis, we examined the exome sequences and copy …

Answer questions and earn CME/CNE Laryngeal cancer remains one of the most common
tumors of the respiratory tract. Fortunately, significant advancements have been made over …

Squamous cell carcinoma arises from multiple anatomic subsites in the head and neck
region. The risk factors for development of cancers of the oral cavity, oropharynx …