Role of KEAP1/NRF2 and TP53 Mutations in Lung Squamous Cell Carcinoma Development and Radiation Resistance
Y Jeong, NT Hoang, A Lovejoy, H Stehr, AM Newman… - Cancer discovery, 2017 - AACR
Lung squamous cell carcinoma (LSCC) pathogenesis remains incompletely understood,
and biomarkers predicting treatment response remain lacking. Here, we describe novel …
and biomarkers predicting treatment response remain lacking. Here, we describe novel …
[HTML][HTML] Multi‑layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/β‑catenin signaling activation
M Katoh - International journal of molecular medicine, 2018 - spandidos-publications.com
β-catenin/CTNNB1 is an intracellular scaffold protein that interacts with adhesion molecules
(E-cadherin/CDH1, N-cadherin/CDH2, VE-cadherin/CDH5 and α-catenins), transmembrane …
(E-cadherin/CDH1, N-cadherin/CDH2, VE-cadherin/CDH5 and α-catenins), transmembrane …
[HTML][HTML] Interplay and cooperation between SREBF1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer
Squamous cell carcinomas (SCCs) comprise one of the most common histologic types of
human cancer. Transcriptional dysregulation of SCC cells is orchestrated by tumor protein …
human cancer. Transcriptional dysregulation of SCC cells is orchestrated by tumor protein …
[HTML][HTML] Recent advances and future directions in clinical management of head and neck squamous cell carcinoma
Simple Summary Even with recent advances, there are urgent needs for novel therapies to
improve overall survival and decrease toxicities in the management of head and neck …
improve overall survival and decrease toxicities in the management of head and neck …
Epigenetic therapeutics: a new weapon in the war against cancer
The past 15 years have seen an explosion of discoveries related to the cellular regulation of
phenotypes through epigenetic mechanisms. This regulation provides a software that …
phenotypes through epigenetic mechanisms. This regulation provides a software that …
Identification of the cell-intrinsic and-extrinsic pathways downstream of EGFR and IFNγ that induce PD-L1 expression in head and neck cancer
Many cancer types, including head and neck cancers (HNC), express programmed death
ligand 1 (PD-L1). Interaction between PD-L1 and its receptor, programmed death 1 (PD-1) …
ligand 1 (PD-L1). Interaction between PD-L1 and its receptor, programmed death 1 (PD-1) …
Deciphering the cells of origin of squamous cell carcinomas
A Sanchez-Danes, C Blanpain - Nature Reviews Cancer, 2018 - nature.com
Squamous cell carcinomas (SCCs) are among the most prevalent human cancers. SCC
comprises a wide range of tumours originated from diverse anatomical locations that share …
comprises a wide range of tumours originated from diverse anatomical locations that share …
Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases
Histone methyltransferases of the nuclear receptor-binding SET domain protein (NSD)
family, including NSD1, NSD2 and NSD3, have crucial roles in chromatin regulation and are …
family, including NSD1, NSD2 and NSD3, have crucial roles in chromatin regulation and are …
Role of oral microbiome on oral cancers, a review
The oral cavity is inhibited by many of the bacterial species. Some of them have a key role in
the development of oral disease. Interrelationships between oral microbiome and systemic …
the development of oral disease. Interrelationships between oral microbiome and systemic …
Current perspectives on nasopharyngeal carcinoma
Abstract Of the~ 129,079 new cases of nasopharyngeal carcinoma (NPC) and 72,987
associated deaths estimated for 2018, the majority will be geographically localized to South …
associated deaths estimated for 2018, the majority will be geographically localized to South …