Abstract UNC-51-like kinase 1 (ULK1), as a serine/threonine kinase, is an autophagic
initiator in mammals and a homologous protein of autophagy related protein (Atg) 1 in yeast …

Autophagy is a key catabolic process, in which cytosolic cargo is engulfed by the formation
of a double membrane and then degraded through the fusing of autophagosomes with …

Oral squamous cell carcinomas (OSCC) and esophageal squamous cell carcinomas
(ESCC) exhibit a survival rate of less than 60% and 40%, respectively. Late‐stage diagnosis …

Autophagy is a highly conserved metabolic process involved in the degradation of
intracellular components including proteins and organelles. Consequently, it plays a critical …

Sirtuin-3 (SIRT3) is an NAD+-dependent protein deacetylase localized primarily in the
mitochondria with many links to different types of human cancers. Autophagy, which is a …

Abstract Sirtuin-1 (SIRT1), the mammalian ortholog of yeast Sir2p, is well known to be a
highly conserved NAD+-dependent protein deacetylase that has been emerging as a key …

Upon the basis of The Cancer Genome Atlas (TCGA) data set, we identified that several
autophagy-related proteins such as AMP-activated protein kinase (AMPK) were remarkably …

Evasion of regulated cell death (RCD), mainly referring to apoptosis, autophagy-dependent
cell death, necroptosis, and other subroutines, is one of the well-established hallmarks of …

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by
a polyglutamine expansion mutation in the huntingtin protein. Expansions above 40 …

Background: Triple-negative breast cancer (TNBC) is one of the most prevalent neoplastic
diseases worldwide, but efficacious treatments for this pathological condition are still …