Bromodomain-containing protein 4 (BRD4) is an attractive epigenetic target in human
cancers. Inhibiting the phosphorylation of BRD4 by casein kinase 2 (CK2) is a potential …

Ferroptosis is a type of programmed cell death resulting from iron overload-dependent lipid
peroxidation, and could be promoted by activating transcription factor 3 (ATF3). SIRT1 is an …

The difficulty of early diagnosis and the development of drug resistance are two major
barriers to the successful treatment of cancer. Autophagy plays a crucial role in several …

Poly (ADP-ribose) polymerase (PARP) inhibitors have been approved for the treatment of
breast cancer (BC) with breast cancer susceptibility (BRCA) gene mutation. Leveraging new …

Autophagy is a critical cellular homeostatic mechanism, and its dysfunction is linked to
invasive breast carcinoma (BRCA). Recently, several omics methods have been applied to …

We herein report the identification, structural optimization, and structure–activity relationship
of thieno [2, 3-d] pyrimidine derivatives as a novel kind of selective vascular endothelial …

Objectives Triple negative breast cancer (TNBC) is a complex and intrinsically aggressive
tumour with poor prognosis, and the discovery of targeted small‐molecule drugs for TNBC …

Membrane biofouling is a challenge to be solved for the stable operation of the seawater
reverse osmosis (SWRO) membrane. This study explored the regulation mechanism of …

In β-thalassemia, accumulated free α-globin forms intracellular precipitates that impair
erythroid cell maturation and viability. Protein quality control systems mitigate β-thalassemia …

Axonal degeneration is a key and early pathological feature in traumatic and
neurodegenerative disorders of the CNS. Following a focal lesion to axons, extended axonal …