UNC-51-like kinase 1 (ULK1), the yeast Atg1 ortholog, is the sole serine-threonine kinase
and initiating enzyme in autophagy, which may be regarded as a target in Parkinson's …

Background Tuberous sclerosis complex (TSC) is a rare genetic multisystemic disorder
resulting from autosomal dominant mutations in the TSC1 or TSC2 genes. It is characterised …

Although macroautophagy/autophagy is involved in hepatocellular carcinoma (HCC)
initiation and development and has been identified as a mechanism of HCC therapy …

Autophagy is an evolutionarily conserved, multi-step lysosomal degradation process for the
clearance of damaged or superfluous proteins and organelles. Accumulating studies have …

Autophagy, a crucial intracellular degradation process facilitated by lysosomes, plays a
pivotal role in maintaining cellular homeostasis. The elucidation of autophagy key genes …

Non-coding RNAs (ncRNAs) have been defined as a class of RNA molecules transcribed
from the genome but not encoding proteins, such as microRNAs, long non-coding RNAs …

Targeted chemotherapy has become the forefront for cancer treatment in recent years. The
selective and specific features allow more effective treatment with reduced side effects. Most …

Radiation‐induced damage to the blood–brain barrier (BBB) is the recognized pathological
basis of radiation‐induced brain injury (RBI), a side effect of head and neck cancer …

ERK1 and ERK5 are proposed to have pivotal roles in several types of cancer. Under some
circumstance, ERK5 may provide a common bypass route, which rescues proliferation upon …

Colorectal cancer (CRC) is a common malignant gastrointestinal tumor with high mortality
worldwide. Drug resistance and cytotoxicity to normal cells are the main causes of …