Eco-friendly synthesis and antifungal evaluation of N-substituted benzimidazoles
D Vargas-Oviedo, E Butassi, S Zacchino… - Monatshefte für Chemie …, 2020 - Springer
A convenient synthesis of N-phenacylbenzimidazoles in high yields (90–95%) by the N-
alkylation reaction of 1 H-benzimidazole with phenacyl bromides is provided. The carbonyl …
alkylation reaction of 1 H-benzimidazole with phenacyl bromides is provided. The carbonyl …
Design, synthesis and structure-activity relationship of a focused library of β-phenylalanine derivatives as novel eEF2K inhibitors with apoptosis-inducing mechanisms …
Y Guo, Y Zhao, G Wang, Y Chen, Y Jiang… - European journal of …, 2018 - Elsevier
Eukaryotic elongation factor 2 kinase (eEF2K) is a Ca 2+/calmudulin-dependent protein
kinase, belonging to a small family of an atypical Ser/Thr-protein kinase. eEF2K has been …
kinase, belonging to a small family of an atypical Ser/Thr-protein kinase. eEF2K has been …
The Pursuit of Enzyme Activation: A Snapshot of the Gold Rush
A range of enzymes drive human physiology, and their activities are tightly regulated
through numerous signaling pathways. Depending on the context, these pathways may …
through numerous signaling pathways. Depending on the context, these pathways may …
Design, synthesis, and biological evaluation of novel dual inhibitors of heat shock protein 90/mammalian target of rapamycin (Hsp90/mTOR) against bladder cancer …
Z Pan, Y Chen, H Pang, X Wang, Y Zhang, X Xie… - European Journal of …, 2022 - Elsevier
In this study, a novel class of thieno [2, 3-d] pyrimidine derivatives containing resorcinol and
morpholine fragments as Hsp90/mTOR dual inhibitors was designed, synthesized, and …
morpholine fragments as Hsp90/mTOR dual inhibitors was designed, synthesized, and …
A pan-cancer assessment of alterations of the kinase domain of ULK1, an upstream regulator of autophagy
M Kumar, E Papaleo - Scientific Reports, 2020 - nature.com
Autophagy is a key clearance process to recycle damaged cellular components. One
important upstream regulator of autophagy is ULK1 kinase. Several three-dimensional …
important upstream regulator of autophagy is ULK1 kinase. Several three-dimensional …
Identification of novel CDK 9 inhibitors based on virtual screening, molecular dynamics simulation, and biological evaluation
M Wu, J Han, Z Liu, Y Zhang, C Huang, J Li, Z Li - Life Sciences, 2020 - Elsevier
Aims Cyclin-dependent kinase 9 (CDK9) is a member of the CDK subfamily and plays a
major role in the regulation of transcriptional elongation. It has attracted widespread …
major role in the regulation of transcriptional elongation. It has attracted widespread …
Cancer cell adaptability: turning ribonucleoprotein granules into targets
M Lavalée, N Curdy, C Laurent, JJ Fournié… - Trends in cancer, 2021 - cell.com
Stress granules (SGs) and processing bodies (P-bodies) are membraneless cytoplasmic
condensates of ribonucleoproteins (RNPs). They both regulate RNA fate under …
condensates of ribonucleoproteins (RNPs). They both regulate RNA fate under …
Cypermethrin activates autophagosome formation albeit inhibits autophagy owing to poor lysosome quality: relevance to Parkinson's disease
AK Mishra, S Mishra, C Rajput, MS ur Rasheed… - Neurotoxicity …, 2018 - Springer
Parkinson's disease (PD) is the second most familiar, progressive and movement-related
neurodegenerative disorder after Alzheimer disease. This study aimed to decipher the role …
neurodegenerative disorder after Alzheimer disease. This study aimed to decipher the role …
Facile construction of irinotecan loaded mesoporous nano-formulation with surface-initiated polymerization to improve stimuli-responsive drug delivery for breast …
Z Nie, D Wang, S Wang, L Wang - Heliyon, 2023 - cell.com
This work uses rice husk to fabricate mesoporous silica nanoparticles (D-RMN) for breast
cancer therapy. The biocompatible dual-responsive (DAN-RMN) was developed by …
cancer therapy. The biocompatible dual-responsive (DAN-RMN) was developed by …
The mechanism of UNC-51-like kinase 1 and the applications of small molecule modulators in cancer treatment
D Sun, Z Zhang, X Yu, H Li, X Wang, L Chen - European Journal of …, 2024 - Elsevier
Autophagy is a process of self-renewal in cells, which not only provides the necessary
nutrients for cells, but also clears necrotic organelles. Autophagy disorders are closely …
nutrients for cells, but also clears necrotic organelles. Autophagy disorders are closely …