Autophagic compound database: a resource connecting autophagy‐modulating compounds, their potential targets and relevant diseases

Y Deng, L Zhu, H Cai, G Wang, B Liu - Cell Proliferation, 2018 - Wiley Online Library
Objectives Autophagy, a highly conserved lysosomal degradation process in eukaryotic
cells, can digest long‐lived proteins and damaged organelles through vesicular trafficking …

[HTML][HTML] In vitro and in vivo models to study the biological and pharmacological properties of queen bee acid (QBA, 10-hydroxy-2-decenoic acid): A systematic review

M Paredes-Barquero, M Niso-Santano… - Journal of Functional …, 2022 - Elsevier
Royal jelly (RJ) is one of the most valued natural products and is considered beneficial to
human health, mainly due to its many biological and pharmacological properties. 10 …

Synthetic activators of autophagy

EA Guseva, JA Pavlova, OA Dontsova… - Biochemistry (Moscow …, 2024 - Springer
Autophagy is a central process for degradation of intracellular components that do not
operate correctly. Molecular mechanisms underlying this process are extremely difficult to …

Targeting autophagy with small-molecule activators for potential therapeutic purposes

Z Fan, LX Wan, W Jiang, B Liu, D Wu - European Journal of Medicinal …, 2023 - Elsevier
Autophagy is well-known to be a lysosome-mediated catabolic process for maintaining
cellular and organismal homeostasis, which has been established with many links to a …

[HTML][HTML] IL-4 activates ULK1/Atg9a/Rab9 in asthma, NLRP3 inflammasomes, and Golgi fragmentation by increasing autophagy flux and mitochondrial oxidative stress

C Xu, Y Song, W Liu, R Liu, Q Bai, L Li, C Wang, G Yan - Redox Biology, 2024 - Elsevier
During asthma, there is an intensification of pulmonary epithelial inflammation,
mitochondrial oxidative stress, and Golgi apparatus fragmentation. However, the underlying …

Unraveling the complexity of histone-arginine methyltransferase CARM1 in cancer: from underlying mechanisms to targeted therapeutics

W Jin, J Zhang, X Chen, S Yin, H Yu, F Gao… - Biochimica et Biophysica …, 2023 - Elsevier
Coactivator-associated arginine methyltransferase 1 (CARM1), a type I protein arginine
methyltransferase (PRMT), has been widely reported to catalyze arginine methylation of …

[HTML][HTML] Autophagy-targeted therapy to modulate age-related diseases: Success, pitfalls, and new directions

WK Martins, MN da Silva, K Pandey, I Maejima… - Current Research in …, 2021 - Elsevier
Autophagy is a critical metabolic process that supports homeostasis at a basal level and is
dynamically regulated in response to various physiological and pathological processes …

Identification of a Locus Near ULK1 Associated With Progression-Free Survival in Ovarian Cancer

MCJ Quinn, K McCue, W Shi, SE Johnatty… - … Biomarkers & Prevention, 2021 - AACR
Background: Many loci have been found to be associated with risk of epithelial ovarian
cancer (EOC). However, although there is considerable variation in progression-free …

Pimavanserin: A novel autophagy modulator for pancreatic cancer treatment

S Ramachandran, IS Kaushik, SK Srivastava - Cancers, 2021 - mdpi.com
Simple Summary Pimavanserin a novel anti-psychotic drug suppresses the growth of
pancreatic tumors in vitro and in vivo and can be developed as a treatment option for …

[HTML][HTML] Targeting the non-canonical roles of PCNA modifies and increases the response to targeted anti-cancer therapy

CK Søgaard, A Nepal, V Petrovic, A Sharma… - Oncotarget, 2019 - ncbi.nlm.nih.gov
Receptor tyrosine kinases (RTKs), such as HER2 and/or EGFR are important therapeutic
targets in multiple cancer cells. Low and/or short response to targeted therapies are often …