[HTML][HTML] Advances in the development of amorphous solid dispersions: The role of polymeric carriers

J Zhang, M Guo, M Luo, T Cai - Asian Journal of Pharmaceutical Sciences, 2023 - Elsevier
Amorphous solid dispersion (ASD) is one of the most effective approaches for delivering
poorly soluble drugs. In ASDs, polymeric materials serve as the carriers in which the drugs …

Effects of additives on the physical stability and dissolution of polymeric amorphous solid dispersions: A review

J Li, Y Wang, D Yu - AAPS PharmSciTech, 2023 - Springer
Polymeric amorphous solid dispersion (ASD) is a popular approach for enhancing the
solubility of poorly water-soluble drugs. However, achieving both physical stability and …

Supersaturable diacyl phospholipid dispersion for improving oral bioavailability of brick dust molecule: A case study of Aprepitant

AS Lale, A Sirvi, S Debaje, S Patil… - European Journal of …, 2024 - Elsevier
This study aims to investigate the potential use of polymer inclusion in the phospholipid-
based solid dispersion approach for augmenting the biopharmaceutical performance of …

Effect of Buffer pH and Concentration on the Dissolution Rates of Sodium Indomethacin–Copovidone and Indomethacin–Copovidone Amorphous Solid Dispersions

CW Chiang, S Tang, C Mao, Y Chen - Molecular Pharmaceutics, 2023 - ACS Publications
The incorporation of counterions into amorphous solid dispersions (ASDs) has been proven
to be effective for improving the dissolution rates of ionizable drugs in ASDs. In this work, the …

Design of Redispersible High-Drug-Load Amorphous Formulations: Impact of Ionic vs Nonionic Surfactants on Processing and Performance

M Yu, HS Oberoi, HS Purohit, CA Fowler… - Molecular …, 2023 - ACS Publications
Amorphous solid dispersions (ASDs) are an enabling formulation approach used to
enhance bioavailability of poorly water-soluble molecules in oral drug products. Drug-rich …

Accelerated stability modeling of recrystallization from amorphous solid Dispersions: A Griseofulvin/HPMC-AS case study

ASC Leon, KC Waterman, G Wang, L Wang… - International Journal of …, 2024 - Elsevier
Amorphous solid dispersions (ASDs) represent an important approach for enhancing oral
bioavailability for poorly water soluble compounds; however, assuring that these ASDs do …

[HTML][HTML] Prevention of Crystal Agglomeration: Mechanisms, Factors, and Impact of Additives

H Zhang, S Du, Y Wang, F Xue - Crystals, 2024 - mdpi.com
Crystal agglomeration is a common phenomenon for most chemicals and pharmaceuticals.
The formation of agglomerates usually lowers product purity and generates a broad particle …

Research on Ternary Solid Dispersions of Celecoxib with Surfactant: Preparation, Characterization, and Solubility Property

T Li, X Fu, Y Wang, F Ouyang, L Liu, M Wen… - Russian Journal of …, 2024 - Springer
Celecoxib (CXB) is a nonsteroidal anti-inflammatory drug (NSAID). However, the application
of CXB has been compromised by its poor aqueous solubility and low oral bioavailability …