Staphylococcal superantigen (SAg) toxins are the most notable virulence factors associated
with Staphylococcus aureus, which is a pathogen associated with serious community and …

Superantigens are powerful microbial toxins that activate the immune system by binding to
class II major histocompatibility complex and T-cell receptor molecules. They cause a …

The constrained backbone torsion angle of a proline (Pro) residue has usually been invoked
to explain its three-dimensional context in proteins. Here we show that specific interactions …

Epstein-Barr virus (EBV) causes infectious mononucleosis, establishes long-term latent
infections, and is associated with a variety of human tumors. The EBV gp42 glycoprotein …

ABSTRACT Staphylococcal Enterotoxins (SEs) have been raising health concerns for food
safety due to their association with staphylococcal foodborne poisoning (SFP). As …

Staphylococcal enterotoxins are prototype superantigens characterized by their ability to
bind to major histocompatibility complex (MHC) class II molecules and subsequently activate …

One of the leading causes of death for women is metastatic breast cancer. Because most
animal tumors do not accurately model clinical metastatic disease, the development of …

Toxic shock syndrome (TSS) is an acute, toxin-mediated illness, like endotoxic shock, and is
characterized by fever, rash, hypotension, multiorgan involvement, and desquamation. TSS …

Staphylococcus aureus and Streptococcus pyogenes (group A streptococci) are Gram‐
positive pathogens capable of producing a variety of bacterial exotoxins known as …

Superantigens trigger an excessive cellular immune response, leading to toxic shock. We
have designed a peptide antagonist that inhibits superantigen-induced expression of human …