Multivalency is one of the hallmarks of antibodies, by which enormous gains in functional
affinity, and thereby improved performance in vivo and in a variety of in vitro assays are …

To enhance the therapeutic efficacy of radioimmunotherapy of cancer, several pretargeting
strategies have been developed. In pretargeted radioimmunotherapy, the tumor is …

An antigen detection system, termed immuno-polymerase chain reaction (immuno-PCR),
was developed in which a specific DNA molecule is used as the marker. A streptavidin …

Antibodies have become the modality of choice within the biopharma industry because they
possess several characteristics that are attractive to those developing therapeutic …

The HER2 protooncogene encodes a 185-kD transmembrane phosphoglycoproteins,
human epidermal growth factor receptor 2 (p185HER2), whose amplified expression on the …

Introduction: Although considerable evidence supports the hypothesis that T cells play a
critical role in the immune response against cancer, the ability to mount and sustain tumor …

It has been 20 years since the publication of Chemistry of Protein Conjugation and Cross-
Linking. During this period, great advances have been made in the area of cross-linking of …

ABSTRACT A bispecific antibody (bsAb) can simultaneously bind two different epitopes or
antigens, allowing for multiple mechanistic functions with synergistic effects. BsAbs have …

In the past decades, the mainstay of systemic therapy for solid and haematological
malignancies was chemotherapy; nevertheless this modality has the drawbacks such as …

Bispecific antibodies are unique macromolecular heterobifunctional cross-linkers with two
different binding specificities within a single molecule. As ideal bioconjugates, they can …