Constipation is among the first nonmotor symptoms to develop in the prodromal phase of
PD. Pathological alpha‐synuclein deposition is present throughout the gastrointestinal tract …

Parkinson's disease (PD) is the second most common neurodegenerative disease. Patients
show deposits of pathological, aggregated α-synuclein not only in the brain but throughout …

Parkinson's disease is characterized by the presence of abnormal, intraneuronal α-
synuclein aggregates, which may propagate from cell-to-cell in a prion-like manner …

Objective To examine the baseline prevalence and longitudinal evolution in non-motor
symptoms (NMS) in a prospective cohort of, at baseline, patients with de novo Parkinson's …

Background Excessive daytime sleepiness (EDS) is common and disabling in Parkinson's
disease (PD). Predictors of EDS are unclear, and data on biological correlates of EDS in PD …

Introduction The clinical, social, and economic implications of Parkinson's disease (PD) are
significant; disability occurs leading to a low quality of life (QoL). Information on the QoL of …

Objective This study was undertaken to determine the frequency and correlates of excessive
daytime sleepiness in de novo, untreated Parkinson's disease (PD) patients compared with …

Background Antipsychotics are frequently and often long‐term used for challenging
behaviour in persons with intellectual disability (ID), but the evidence base for this is …

Introducción Conocer el alcance socieoeconómico de la enfermedad de Parkinson es
esencial para la planificación de recursos y concienciación social. Desarrollo Se ha …

Background Gastrointestinal dysfunction is an important feature of Parkinson's disease (PD),
and there is increasing evidence that it may play a key role in the disease process. However …