The light sensor of vertebrate scotopic (low-light) vision, rhodopsin, is a G-protein-coupled
receptor comprising a polypeptide chain with bound chromophore, 11-cis-retinal, that …

The fatty acid composition of photoreceptor outer segment (POS) phospholipids diverges
from other membranes, being highly enriched in polyunsaturated fatty acids (PUFAs). The …

Oxidative stress has been implicated in the pathogenesis of age-related macular
degeneration, the leading cause of blindness in older adults, with retinal pigment epithelium …

Stargardt maculopathy, caused predominantly by mutations in the ABCA4 gene, is
characterized by an accumulation of non-degradable visual pigment derivative, lipofuscin, in …

Lipids serve many roles in the neural system, from synaptic stabilization and signaling to
DNA regulation and neuroprotection. They also regulate inflammatory responses, maintain …

Lipofuscin accumulates with age as intracellular fluorescent granules originating from
incomplete lysosomal digestion of phagocytosed and autophagocytosed material. The …

Abstract Adiponectin receptor 1 (ADIPOR1) is a lipid and glucose metabolism regulator that
possesses intrinsic ceramidase activity. Mutations of the ADIPOR1 gene have been …

The widespread presence of mercury, a heavy metal found in the environment and used in
numerous industries and domestic, raises concerns about its potential impact on human …

Introduction The vertebrate retinal pigment epithelium (RPE) lies adjacent to the
photoreceptors and is responsible for the engulfment and degradation of shed …

Resolvin E1 (RvE1) is an eicosapentaenoic acid-derived lipid mediator involved in the
resolution of inflammation. Here, we investigated whether RvE1 alterations may occur in an …