Neurotoxic effects of aluminium exposure as a potential risk factor for Alzheimer's disease

M Dey, RK Singh - Pharmacological Reports, 2022 - Springer
Aluminium is one of the most widely distributed elements of the Earth's crust. Its routine use
has resulted in excessive human exposure and due to the potential neurotoxic effects has …

Mitochondrial Dysfunction and Alpha‐Lipoic Acid: Beneficial or Harmful in Alzheimer's Disease?

SM Dos Santos, CFR Romeiro… - Oxidative medicine …, 2019 - Wiley Online Library
Alzheimer's disease (AD) is a neurodegenerative disorder characterised by impairments in
the cognitive domains associated with orientation, recording, and memory. This pathology …

[HTML][HTML] Aluminium-induced acute neurotoxicity in rats: Treatment with aqueous extract of Arthrophytum (Hammada scoparia)

K Taïr, O Kharoubi, OA Taïr, N Hellal, I Benyettou… - Journal of acute …, 2016 - Elsevier
Objective To study the antioxidative and protective properties of aqueous extract of
Hammada scoparia (H. scoparia) against the effects of sub-chronic aluminium (Al) …

[HTML][HTML] Potential therapeutic effects of lipoic acid on memory deficits related to aging and neurodegeneration

P Molz, N Schröder - Frontiers in pharmacology, 2017 - frontiersin.org
The aging process comprises a series of organic alterations, affecting multiple systems,
including the nervous system. Aging has been considered the main risk factor for the …

Alpha lipoic acid ameliorates scopolamine induced memory deficit and neurodegeneration in the cerebello-hippocampal cortex

AE Memudu, AE Adewumi - Metabolic brain disease, 2021 - Springer
Scopolamine-induced memory loss is used to study new drug discovery in Alzheimer's
disease (AD) pathogenesis. This study was aimed at evaluating the role of an antioxidant …

[HTML][HTML] Evaluation of dissolution profiles of a newly developed solid oral immediate-release formula containing alpha-lipoic acid

AL Pop, S Crișan, M Bârcă, AM Ciobanu, VN Varlas… - Processes, 2021 - mdpi.com
Alpha-lipoic acid (ALA, thioctic acid), a naturally-occurring essential dithiol compound, has
become a common ingredient in many pharmaceutical and food supplement products (FSP) …

The protective effect of alpha lipoic acid (ALA) on social interaction memory, but not passive avoidance in sleep-deprived rats

M Rezaie, M Nasehi, S Vaseghi… - Naunyn-Schmiedeberg's …, 2020 - Springer
Sleep is involved in maintaining energy, regulating heat, and recovering tissues.
Furthermore, proper cognitive functions need sufficient sleep. Many studies have revealed …

Chlorogenic acid protects against aluminum toxicity via MAPK/Akt signaling pathway in murine RAW264. 7 macrophages

D Cheng, X Zhang, J Tang, Y Kong, X Wang… - Journal of Inorganic …, 2019 - Elsevier
Aluminum (Al), which may bring about damage to the macrophages, has been implicated in
the development of immunological diseases. It has been reported that chlorogenic acid …

[HTML][HTML] α-Lipoic Acid Maintains Brain Glucose Metabolism via BDNF/TrkB/HIF-1α Signaling Pathway in P301S Mice

Y Zhang, X Yan, S Xu, Z Pang, L Li, Y Yang… - Frontiers in Aging …, 2020 - frontiersin.org
The microtubule-associated protein tau is closely correlated with hypometabolism in
Alzheimer's disease (AD). α-lipoic acid (LA), which is a naturally occurring cofactor in …

Memory enhancing effect of black pepper in the AlCl3 induced neurotoxicity mouse model is mediated through its active component chavicine

G Iqbal, A Iqbal, A Mahboob… - Current …, 2016 - ingentaconnect.com
Black pepper (Piper nigrum Linn.) has vital pharmacological properties with profound effects
on central nervous system. Neurotoxic agents like Aluminum Chloride (AlCl3) cause the …