Leptin and obesity: role and clinical implication

M Obradovic, E Sudar-Milovanovic, S Soskic… - Frontiers in …, 2021 - frontiersin.org
The peptide hormone leptin regulates food intake, body mass, and reproductive function and
plays a role in fetal growth, proinflammatory immune responses, angiogenesis and lipolysis …

Obesity and diabetes as high‐risk factors for severe coronavirus disease 2019 (Covid‐19)

Y Zhou, J Chi, W Lv, Y Wang - Diabetes/metabolism research …, 2021 - Wiley Online Library
The outbreak of the coronavirus disease 2019 (Covid‐19) has become an evolving
worldwide health crisis. With the rising prevalence of obesity and diabetes has come an …

Molecular pathways of nonalcoholic fatty liver disease development and progression

F Bessone, MV Razori, MG Roma - Cellular and Molecular Life Sciences, 2019 - Springer
Nonalcoholic fatty liver disease (NAFLD) is a main hepatic manifestation of metabolic
syndrome. It represents a wide spectrum of histopathological abnormalities ranging from …

Adipogenesis as a potential anti-obesity target: A review of pharmacological treatment and natural products

J Jakab, B Miškić, Š Mikšić, B Juranić… - … syndrome and obesity, 2021 - Taylor & Francis
Obesity is recognized as a severe threat to overall human health and is associated with type
2 diabetes mellitus, dyslipidemia, hypertension, and cardiovascular diseases. Abnormal …

Leptin as a key regulator of the adipose organ

C Picó, M Palou, CA Pomar, AM Rodríguez… - Reviews in Endocrine …, 2022 - Springer
Leptin is a hormone primarily produced by the adipose tissue in proportion to the size of fat
stores, with a primary function in the control of lipid reserves. Besides adipose tissue, leptin …

Role of leptin in inflammation and vice versa

A Pérez-Pérez, F Sánchez-Jiménez… - International journal of …, 2020 - mdpi.com
Inflammation is an essential immune response for the maintenance of tissue homeostasis. In
a general sense, acute and chronic inflammation are different types of adaptive response …

Aging and the immune system: An overview

AAS Akha - Journal of immunological methods, 2018 - Elsevier
The world is witnessing a rapid demographic shift towards an older population, a trend with
major medical, social, economic and political implications. Aging is a multifaceted process …

Aging, male sex, obesity, and metabolic inflammation create the perfect storm for COVID-19

F Mauvais-Jarvis - Diabetes, 2020 - Am Diabetes Assoc
Coronavirus disease 2019 (COVID-19) is a novel threat that seems to result from the
collusion between a new pandemic of severe acute respiratory syndrome coronavirus 2 …

Tissue-specific effects of leptin on glucose and lipid metabolism

S Pereira, DL Cline, MM Glavas, SD Covey… - Endocrine …, 2021 - academic.oup.com
The discovery of leptin was intrinsically associated with its ability to regulate body weight.
However, the effects of leptin are more far-reaching and include profound glucose-lowering …

[HTML][HTML] Pathophysiology of obesity and its associated diseases

X Jin, T Qiu, L Li, R Yu, X Chen, C Li, CG Proud… - … Pharmaceutica Sinica B, 2023 - Elsevier
The occurrence of obesity has increased across the whole world. Many epidemiological
studies have indicated that obesity strongly contributes to the development of cancer …