The serotonin hypothesis of depression is still influential. We aimed to synthesise and
evaluate evidence on whether depression is associated with lowered serotonin …

Objective To assess the comparative effectiveness of exercise, antidepressants and their
combination for alleviating depressive symptoms in adults with non-severe depression …

Survey-based studies suggest naturalistic psychedelic use provides mental health benefits
similar to those observed in clinical trials. The current study sought to confirm these findings …

The theory that depression is caused by a serotonin abnormality or other chemical
imbalance has become widely accepted by the public and is one prominent justification for …

Objective: To test esmethadone (REL-1017) as adjunctive treatment in patients with major
depressive disorder (MDD) and inadequate response to standard antidepressants. Methods …

Background: Stopping antidepressants commonly causes withdrawal symptoms, which can
be severe and long-lasting. National Institute for Health and Care Excellence (NICE) …

The landscape of mental health care and service delivery is changing, as is our
understanding of the underlying causes for mental distress. It is now apparent that biogenic …

The efficacy of antidepressants in the acute treatment of moderate-to-severe depression
remains a controversial issue. The minimal important difference (MID) is relevant to judge …

We thank the authors of all the letters for their interest in our paper [1]. The reason our paper
is important is that the pharmaceutical industry, along with many doctors and academics …

Well before COVID-19, there was growing excitement about the potential of various digital
technologies such as tele-health, smartphone apps, or AI chatbots to revolutionize mental …