Recent antimalarial drug discovery has been a race to produce new medicines that
overcome emerging drug resistance, whilst considering safety and improving dosing …

Plasmodium spp. parasites are the causative agents of malaria in humans and animals, and
they are exceptionally diverse in their morphology and life cycles. They grow and develop in …

Protozoan diseases continue to be a worldwide social and economic health problem.
Increased drug resistance, emerging cross resistance, and lack of new drugs with novel …

Preventing human-to-mosquito transmission of malaria parasites provides possible
solutions to interrupt the malaria parasite life cycle for malaria elimination. The development …

Malaria is a global parasitic infection that leads to substantial illness and death. The most
commonly-used drugs for treatment of malaria vivax are primaquine and chloroquine, but …

Tafenoquine is a newly licensed antimalarial drug for the radical cure of Plasmodium vivax
malaria. The mechanism of action and optimal dosing are uncertain. We pooled individual …

The ongoing pandemic of coronavirus disease-2019 (COVID-19) is being caused by severe
acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The disease continues to present …

Abstract Primaquine (PQ), an 8-aminoquinoline antimalarial drug, has been widely used for
the eradication of hypnozoites from the liver and, therefore, recognized as the radical cure of …

Infections with Plasmodium falciparum and Plasmodium vivax cause over 600,000 deaths
each year, concentrated in Africa and in young children, but much of the world's population …

Plasmodium vivax is the most geographically widespread cause of human malaria and is
responsible for the majority of cases outside of the African continent. While great progress …