Metformin is a widely used drug in today's prescriptions by physicians due to its specific
effects in treating and curing type II diabetes. Diabetes is a common disease that may occur …

Tumor cells harbor genetic alterations that promote a continuous and elevated production of
reactive oxygen species. Whereas such oxidative stress conditions would be harmful to …

Oxidative phosphorylation (OXPHOS) takes place in mitochondria and is the process
whereby cells use carbon fuels and oxygen to generate ATP. Formerly OXPHOS was …

Mitochondria have a well-recognized role in the production of ATP and the intermediates
needed for macromolecule biosynthesis, such as nucleotides. Mitochondria also participate …

Pancreatic ductal adenocarcinoma, as one of the most aggressive cancers, is characterized
by rich desmoplastic stroma that forms a physical barrier for anticancer drugs. To address …

It is long recognized that cancer cells display increased glucose uptake and metabolism. In
a rate-limiting step for glucose metabolism, the glucose transporter (GLUT) proteins facilitate …

Importance Unresected locally advanced non–small cell lung cancer (LA-NSCLC) shows
poor survival outcomes even after aggressive concurrent chemoradiotherapy. Whether …

In recent years, several studies have presented evidence suggesting a potential role for
metformin in anti-cancer therapy. Preclinical studies have demonstrated several anticancer …

Malignant tumors are often multifactorial. Epidemiological studies have shown that
hyperglycemia raises the prevalence and mortality of certain malignancies, like breast, liver …

Importance Non–small cell lung cancer (NSCLC) has relatively poor outcomes. Metformin
has significant data supporting its use as an antineoplastic agent. Objective To compare …