Crosstalk between cancer and immune cells: Role of tumor‐associated macrophages in the tumor microenvironment
J Wang, D Li, H Cang, B Guo - Cancer medicine, 2019 - Wiley Online Library
Tumor microenvironment is a complex system that contains multiple cells and cytokines.
Among the multiple immune cells, macrophage is particularly abundant and plays an …
Among the multiple immune cells, macrophage is particularly abundant and plays an …
Inflammation: gearing the journey to cancer
JK Kundu, YJ Surh - Mutation Research/Reviews in Mutation Research, 2008 - Elsevier
Chronic inflammation plays a multifaceted role in carcinogenesis. Mounting evidence from
preclinical and clinical studies suggests that persistent inflammation functions as a driving …
preclinical and clinical studies suggests that persistent inflammation functions as a driving …
[HTML][HTML] The AOM/DSS murine model for the study of colon carcinogenesis: From pathways to diagnosis and therapy studies
M De Robertis, E Massi, ML Poeta, S Carotti… - Journal of …, 2011 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) is a major health problem in industrialized countries. Although
inflammation-linked carcinogenesis is a well accepted concept and is often observed within …
inflammation-linked carcinogenesis is a well accepted concept and is often observed within …
Butyrate inhibits inflammatory responses through NFκB inhibition: implications for Crohn's disease
JP Segain, DR De La Blétiere, A Bourreille, V Leray… - Gut, 2000 - gut.bmj.com
BACKGROUND/AIM Proinflammatory cytokines are key factors in the pathogenesis of
Crohn's disease (CD). Activation of nuclear factor kappa B (NFκB), which is involved in their …
Crohn's disease (CD). Activation of nuclear factor kappa B (NFκB), which is involved in their …
Infliximab as rescue therapy in severe to moderately severe ulcerative colitis: a randomized, placebo-controlled study
G Järnerot, E Hertervig, I Friis-Liby, L Blomquist… - Gastroenterology, 2005 - Elsevier
Background & Aims: Despite treatment with corticosteroids, severe to moderately severe
attacks of ulcerative colitis have a high colectomy rate. We intended to find a rescue therapy …
attacks of ulcerative colitis have a high colectomy rate. We intended to find a rescue therapy …
The association of tissue anti-TNF drug levels with serological and endoscopic disease activity in inflammatory bowel disease: the ATLAS study
AJ Yarur, A Jain, DA Sussman, JS Barkin, MA Quintero… - Gut, 2016 - gut.bmj.com
Objective The aim of this study was to assess the correlation between serum and intestinal
anti-tumour necrosis factor (TNF) levels, and their relationship to endoscopic disease activity …
anti-tumour necrosis factor (TNF) levels, and their relationship to endoscopic disease activity …
The luminal short-chain fatty acid butyrate modulates NF-κB activity in a human colonic epithelial cell line
MS Inan, RJ Rasoulpour, L Yin, AK Hubbard… - Gastroenterology, 2000 - Elsevier
Background & Aims: The transcription factor nuclear factor–κB (NF-κB) plays a central role in
regulating immune and inflammatory responses. Because butyrate deficiency has been …
regulating immune and inflammatory responses. Because butyrate deficiency has been …
Emerging avenues linking inflammation and cancer
JK Kundu, YJ Surh - Free Radical Biology and Medicine, 2012 - Elsevier
The role of inflammation in carcinogenesis has been extensively investigated and well
documented. Many biochemical processes that are altered during chronic inflammation …
documented. Many biochemical processes that are altered during chronic inflammation …
Tumour necrosis factor-α as a tumour promoter
P Szlosarek, KA Charles, FR Balkwill - European journal of cancer, 2006 - Elsevier
It is becoming more evident that many aspects of tumour promotion arise from persistent and
unresolving inflammation. One of the key molecules mediating the inflammatory processes …
unresolving inflammation. One of the key molecules mediating the inflammatory processes …
Infliximab induces apoptosis in monocytes from patients with chronic active Crohn's disease by using a caspase-dependent pathway
A Lügering, M Schmidt, N Lügering, HG Pauels… - Gastroenterology, 2001 - Elsevier
Background & Aims: Treatment with a chimeric anti-tumor necrosis factor (TNF) antibody
(infliximab) has been shown to be highly efficient for patients with steroid-refractory Crohn's …
(infliximab) has been shown to be highly efficient for patients with steroid-refractory Crohn's …