Tumor microenvironment is a complex system that contains multiple cells and cytokines.
Among the multiple immune cells, macrophage is particularly abundant and plays an …

Chronic inflammation plays a multifaceted role in carcinogenesis. Mounting evidence from
preclinical and clinical studies suggests that persistent inflammation functions as a driving …

Colorectal cancer (CRC) is a major health problem in industrialized countries. Although
inflammation-linked carcinogenesis is a well accepted concept and is often observed within …

BACKGROUND/AIM Proinflammatory cytokines are key factors in the pathogenesis of
Crohn's disease (CD). Activation of nuclear factor kappa B (NFκB), which is involved in their …

Background & Aims: Despite treatment with corticosteroids, severe to moderately severe
attacks of ulcerative colitis have a high colectomy rate. We intended to find a rescue therapy …

Objective The aim of this study was to assess the correlation between serum and intestinal
anti-tumour necrosis factor (TNF) levels, and their relationship to endoscopic disease activity …

Background & Aims: The transcription factor nuclear factor–κB (NF-κB) plays a central role in
regulating immune and inflammatory responses. Because butyrate deficiency has been …

The role of inflammation in carcinogenesis has been extensively investigated and well
documented. Many biochemical processes that are altered during chronic inflammation …

It is becoming more evident that many aspects of tumour promotion arise from persistent and
unresolving inflammation. One of the key molecules mediating the inflammatory processes …

Background & Aims: Treatment with a chimeric anti-tumor necrosis factor (TNF) antibody
(infliximab) has been shown to be highly efficient for patients with steroid-refractory Crohn's …