The α and β cells act in concert to maintain blood glucose. The α cells release glucagon in
response to low levels of glucose to stimulate glycogenolysis in the liver. In contrast, β cells …

Several studies indicate that the PI3K/PTEN/AKT signaling pathways are critical regulators
of ovarian function including the formation of the germ cell precursors, termed primordial …

Molecular mechanisms of ovarian aging and female age-related fertility decline remain
unclear. We surveyed the single-cell transcriptomic landscape of ovaries from young and …

Aneuploidy in fetal chromosomes is one of the causes of pregnancy loss and of congenital
birth defects. It is known that the frequency of oocyte aneuploidy increases with the human …

Puberty is a complex physiological event by which animals mature into an adult capable of
sexual reproduction. In order to enhance our understanding of the genes and regulatory …

Implantation of the embryo into the endometrium is a critical step in the establishment of
pregnancy and the failure of embryos to implant is a major limiting factor in the success of …

Background Genetic progress for fertility and reproduction traits in dairy cattle has been
limited due to the low heritability of most indicator traits. Moreover, most of the quantitative …

Understanding the unique mechanisms of human oogenesis necessitates the development
of an in vitro system of stem cell differentiation into oocytes. Specialized cell types and …

STUDY QUESTION Do specific transcriptome dynamics in human oocytes from primordial
and primary follicles identify novel pathways in oocyte activation? SUMMARY ANSWER The …

The reproductive and endocrine functions of the ovary involve spatially defined interactions
among specialized cell populations. Despite the ovary's importance in fertility and endocrine …