Amyloid-β (Aβ) pathology is one of the earliest detectable brain changes in Alzheimer's
disease (AD) pathogenesis. The overall load and spatial distribution of brain Aβ can be …

Background Amyloid-β (Aβ) accumulation is considered the earliest pathological change in
Alzheimer's disease (AD). The Amyloid Imaging to Prevent Alzheimer's Disease (AMYPAD) …

Purpose Amyloid positron emission tomography (PET) with [18F] florbetaben (FBB) is an
established tool for detecting Aβ deposition in the brain in vivo based on visual assessment …

Purpose To investigate the sensitivity of visual read (VR) to detect early amyloid pathology
and the overall utility of regional VR. Methods [18 F] Flutemetamol PET images of 497 …

Background The mismatch between the limited availability versus the high demand of
participants who are in the pre-dementia phase of Alzheimer's disease (AD) is a bottleneck …

White matter hyperintensities (WMHs) have a heterogeneous aetiology, associated with both
vascular risk factors and amyloidosis due to Alzheimer's disease. While spatial distribution of …

Previous multicenter imaging studies with 18F-FDG PET have established the presence of
motor-related and cognition-related metabolic patterns of Parkinson disease (PD), termed …

Background A low amount and extent of Aβ deposition at early stages of Alzheimer's
disease (AD) may limit the use of previously developed pathology-proven composite SUVR …

Cognitive health is a life-long concern affected by modifiable risk factors, including lifestyle
choices, such as dietary intake, with serious implications for quality of life, morbidity, and …

Background Detecting subtle-to-moderate biomarker changes such as those in amyloid PET
imaging becomes increasingly relevant in the context of primary and secondary prevention …