Phase separation drives tumor pathogenesis and evolution: All roads lead to Rome

X Gu, A Zhuang, J Yu, P Chai, R Jia, J Ruan - Oncogene, 2022 - nature.com
Cells coordinate numerous biochemical reactions in space and time, depending on the
subdivision of the intracellular space into functional compartments. Compelling evidence …

[HTML][HTML] OpenABC enables flexible, simplified, and efficient GPU accelerated simulations of biomolecular condensates

S Liu, C Wang, AP Latham, X Ding… - PLoS Computational …, 2023 - journals.plos.org
Biomolecular condensates are important structures in various cellular processes but are
challenging to study using traditional experimental techniques. In silico simulations with …

Diverse roles of biomolecular condensation in eukaryotic translational regulation

Y Zhang, JY Kang, M Liu, Y Huang - RNA biology, 2023 - Taylor & Francis
Biomolecular condensates, forming membrane-less organelles, orchestrate the sub-cellular
compartment to execute designated biological processes. An increasing body of evidence …

Phase separation of Myc differentially regulates gene transcription

J Yang, CI Chung, J Koach, H Liu, Q Zhao, X Yang… - BioRxiv, 2022 - biorxiv.org
Dysregulation and enhanced expression of MYC transcription factors including MYC and
MYCN contribute to majority of human cancers. For example, MYCN is amplified up to …

α‐Pinene inhibits the growth of cervical cancer cells through its proapoptotic activity by regulating the miR‐34a‐5p/Bcl‐2 signaling axis

X Huang, P Yan, W Ding, C Zhou, Q Xu… - Drug Development …, 2022 - Wiley Online Library
Among gynecological tumors, cervical cancer (CC) has the second‐highest prevalence and
mortality rate. α‐Pinene is a bicyclic monoterpenoid compound extracted from pine needles …

[HTML][HTML] p62 promotes the mitochondrial localization of p53 through its UBA domain and participates in regulating the sensitivity of ovarian cancer cells to cisplatin

Q Kong, X Yan, M Cheng, X Jiang, L Xu… - International Journal of …, 2022 - mdpi.com
Chemotherapeutic drug-induced p53-dependent crosstalk among tumor cells affects the
sensitivity of tumor cells to chemotherapeutic drugs, contributing to chemoresistance …

[HTML][HTML] From the catastrophic objective irreproducibility of cancer research and unavoidable failures of molecular targeted therapies to the sparkling hope of …

I Alekseenko, L Kondratyeva, I Chernov… - International Journal of …, 2023 - mdpi.com
The unprecedented non-reproducibility of the results published in the field of cancer
research has recently come under the spotlight. In this short review, we try to highlight some …

Through the lens of phase separation: intrinsically unstructured protein and chromatin looping

L Cai, GG Wang - Nucleus, 2023 - Taylor & Francis
The establishment, maintenance and dynamic regulation of three-dimensional (3D)
chromatin structures provide an important means for partitioning of genome into functionally …

[HTML][HTML] Macromolecular crowding is surprisingly unable to deform the structure of a model biomolecular condensate

JC Shillcock, DB Thomas, JH Ipsen, AD Brown - Biology, 2023 - mdpi.com
Simple Summary The cytoplasm of a living cell is a crowded place, containing hundreds of
types of protein and other macromolecules. Cells reliably and continually perform thousands …

[HTML][HTML] Filamentation and biofilm formation are regulated by the phase-separation capacity of network transcription factors in Candida albicans

C Ganser, MI Staples, M Dowell, C Frazer… - Plos …, 2023 - journals.plos.org
The ability of the fungus Candida albicans to filament and form biofilms contributes to its
burden as a leading cause of hospital-acquired infections. Biofilm development involves an …