Phase separation drives tumor pathogenesis and evolution: All roads lead to Rome
X Gu, A Zhuang, J Yu, P Chai, R Jia, J Ruan - Oncogene, 2022 - nature.com
Cells coordinate numerous biochemical reactions in space and time, depending on the
subdivision of the intracellular space into functional compartments. Compelling evidence …
subdivision of the intracellular space into functional compartments. Compelling evidence …
[HTML][HTML] OpenABC enables flexible, simplified, and efficient GPU accelerated simulations of biomolecular condensates
Biomolecular condensates are important structures in various cellular processes but are
challenging to study using traditional experimental techniques. In silico simulations with …
challenging to study using traditional experimental techniques. In silico simulations with …
Diverse roles of biomolecular condensation in eukaryotic translational regulation
Y Zhang, JY Kang, M Liu, Y Huang - RNA biology, 2023 - Taylor & Francis
Biomolecular condensates, forming membrane-less organelles, orchestrate the sub-cellular
compartment to execute designated biological processes. An increasing body of evidence …
compartment to execute designated biological processes. An increasing body of evidence …
Phase separation of Myc differentially regulates gene transcription
Dysregulation and enhanced expression of MYC transcription factors including MYC and
MYCN contribute to majority of human cancers. For example, MYCN is amplified up to …
MYCN contribute to majority of human cancers. For example, MYCN is amplified up to …
α‐Pinene inhibits the growth of cervical cancer cells through its proapoptotic activity by regulating the miR‐34a‐5p/Bcl‐2 signaling axis
X Huang, P Yan, W Ding, C Zhou, Q Xu… - Drug Development …, 2022 - Wiley Online Library
Among gynecological tumors, cervical cancer (CC) has the second‐highest prevalence and
mortality rate. α‐Pinene is a bicyclic monoterpenoid compound extracted from pine needles …
mortality rate. α‐Pinene is a bicyclic monoterpenoid compound extracted from pine needles …
[HTML][HTML] p62 promotes the mitochondrial localization of p53 through its UBA domain and participates in regulating the sensitivity of ovarian cancer cells to cisplatin
Q Kong, X Yan, M Cheng, X Jiang, L Xu… - International Journal of …, 2022 - mdpi.com
Chemotherapeutic drug-induced p53-dependent crosstalk among tumor cells affects the
sensitivity of tumor cells to chemotherapeutic drugs, contributing to chemoresistance …
sensitivity of tumor cells to chemotherapeutic drugs, contributing to chemoresistance …
[HTML][HTML] From the catastrophic objective irreproducibility of cancer research and unavoidable failures of molecular targeted therapies to the sparkling hope of …
I Alekseenko, L Kondratyeva, I Chernov… - International Journal of …, 2023 - mdpi.com
The unprecedented non-reproducibility of the results published in the field of cancer
research has recently come under the spotlight. In this short review, we try to highlight some …
research has recently come under the spotlight. In this short review, we try to highlight some …
Through the lens of phase separation: intrinsically unstructured protein and chromatin looping
L Cai, GG Wang - Nucleus, 2023 - Taylor & Francis
The establishment, maintenance and dynamic regulation of three-dimensional (3D)
chromatin structures provide an important means for partitioning of genome into functionally …
chromatin structures provide an important means for partitioning of genome into functionally …
[HTML][HTML] Macromolecular crowding is surprisingly unable to deform the structure of a model biomolecular condensate
JC Shillcock, DB Thomas, JH Ipsen, AD Brown - Biology, 2023 - mdpi.com
Simple Summary The cytoplasm of a living cell is a crowded place, containing hundreds of
types of protein and other macromolecules. Cells reliably and continually perform thousands …
types of protein and other macromolecules. Cells reliably and continually perform thousands …
[HTML][HTML] Filamentation and biofilm formation are regulated by the phase-separation capacity of network transcription factors in Candida albicans
C Ganser, MI Staples, M Dowell, C Frazer… - Plos …, 2023 - journals.plos.org
The ability of the fungus Candida albicans to filament and form biofilms contributes to its
burden as a leading cause of hospital-acquired infections. Biofilm development involves an …
burden as a leading cause of hospital-acquired infections. Biofilm development involves an …