WNT-signaling controls important cellular processes throughout embryonic development
and adult life, so any deregulation of this signaling can result in a wide range of pathologies …

In human skin, melanogenesis is a tightly regulated process. Indeed, several extracellular
signals are transduced via dedicated signalling pathways and mostly converge to MITF, a …

We present SCENIC, a computational method for simultaneous gene regulatory network
reconstruction and cell-state identification from single-cell RNA-seq data (http://scenic …

Nearly 15% of melanomas occur in patients with a family history and a subset of these
patients have a germline mutation in a melanoma predisposing gene. CDKN2A mutations …

Simple Summary Malignant melanoma is more dangerous than most other skin cancers due
to its ability to spread early and aggressively. Until the development of new therapeutic …

Drug resistance constitutes a major challenge in designing melanoma therapies.
Microenvironment-driven tumor heterogeneity and plasticity play a key role in this …

Pigment production is a unique character of melanocytes. Numerous factors are linked with
melanin production, including genetics, ultraviolet radiation (UVR) and inflammation …

Melanoma is a cutaneous neoplastic growth of melanocytes with great potential to invade
and metastasize, especially when not treated early and effectively. Epithelial-mesenchymal …

Abnormal melanin synthesis upon UV exposure causes excessive oxidative stress, which
leads to skin hyperpigmentation disorders such as freckles, melisma, and age spots. The …

Dysregulation of the activity of the mechanistic target of rapamycin complex 1 (mTORC1) is
commonly linked to aging, cancer, and genetic disorders such as tuberous sclerosis (TS), a …