Hearing loss is the most common sensory deficit experienced by humans and represents
one of the largest chronic health conditions worldwide. It is expected that around 10% of the …

Extracellular vesicles (EVs) are highly promising as drug delivery vehicles due to their
nanoscale size, stability and biocompatibility. EVs possess natural targeting abilities and are …

Background Mesenchymal stem cell (MSC) transplantation is a promising therapeutic
approach for noise-induced hearing loss (NIHL). As the indispensable role of apoptosis in …

Hearing loss impacts the quality of life and affects communication resulting in social isolation
and reduced well-being. Despite its impact on society and economy, no therapies for age …

Hearing impairment is the most common sensory disorder in humans, and yet hardly any
medications are licensed for the treatment of inner ear pathologies. Intricate …

The use of anti-oxidants could thus prove an effective medication to prevent or facilitate
recovery from oxidative stress-induced sensorineural hearing loss (SNHL). One promising …

Introduction Sensorineural hearing loss results in irreversible loss of inner ear hair cells and
spiral ganglion neurons. Reduced sound detection and speech discrimination can span all …

Sensorineural hearing loss is very difficult to treat. Currently, one of the techniques used for
hearing rehabilitation is a cochlear implant that can transform sound into electrical signals …

Systemic drug administration provides convenience and non-invasive benefits for
preventing and treating inner ear diseases. However, the blood-labyrinth barrier (BLB) …

Substantial efforts have been made for local administration of small molecules or biologics
in treating hearing loss diseases caused by either trauma, genetic mutations, or drug …