Insulin signaling and heart failure

C Riehle, ED Abel - Circulation research, 2016 - Am Heart Assoc
Heart failure is associated with generalized insulin resistance. Moreover, insulin-resistant
states such as type 2 diabetes mellitus and obesity increases the risk of heart failure even …

[HTML][HTML] Impact of obesity-induced inflammation on cardiovascular diseases (CVD)

G Battineni, GG Sagaro, N Chintalapudi… - International Journal of …, 2021 - mdpi.com
Overweight and obesity are key risk factors of cardiovascular disease (CVD). Obesity is
currently presented as a pro-inflammatory state with an expansion in the outflow of …

Human epicardial adipose tissue induces fibrosis of the atrial myocardium through the secretion of adipo-fibrokines

N Venteclef, V Guglielmi, E Balse, B Gaborit… - European heart …, 2015 - academic.oup.com
Aims Recent studies have reported a relationship between the abundance of epicardial
adipose tissue (EAT) and the risk of cardiovascular diseases including atrial fibrillation (AF) …

Epicardial adipose tissue as a metabolic transducer: role in heart failure and coronary artery disease

VB Patel, S Shah, S Verma, GY Oudit - Heart failure reviews, 2017 - Springer
Obesity and diabetes are strongly associated with metabolic and cardiovascular disorders
including dyslipidemia, coronary artery disease, hypertension, and heart failure. Adipose …

Cardiorenal syndrome type 1: pathophysiological crosstalk leading to combined heart and kidney dysfunction in the setting of acutely decompensated heart failure

C Ronco, M Cicoira, PA McCullough - Journal of the American College of …, 2012 - jacc.org
Cardiorenal syndrome (CRS) type 1 is characterized as the development of acute kidney
injury (AKI) and dysfunction in the patient with acute cardiac illness, most commonly acute …

Perivascular adipose tissue in vascular function and disease: a review of current research and animal models

NK Brown, Z Zhou, J Zhang, R Zeng, J Wu… - … , and vascular biology, 2014 - Am Heart Assoc
Perivascular adipose tissue (PVAT), long assumed to be nothing more than vessel-
supporting connective tissue, is now understood to be an important, active component of the …

Adipose tissue and its role in organ crosstalk

T Romacho, M Elsen, D Röhrborn, J Eckel - Acta physiologica, 2014 - Wiley Online Library
The discovery of adipokines has revealed adipose tissue as a central node in the interorgan
crosstalk network, which mediates the regulation of multiple organs and tissues. Adipose …

Adipokines: a treasure trove for the discovery of biomarkers for metabolic disorders

S Lehr, S Hartwig, H Sell - PROTEOMICS–Clinical Applications, 2012 - Wiley Online Library
Adipose tissue is a major endocrine organ, releasing signaling and mediator proteins,
termed adipokines, via which adipose tissue communicates with other organs. Expansion of …

Endothelial dysfunction, obesity and insulin resistance

D Prieto, C Contreras, A Sánchez - Current vascular …, 2014 - ingentaconnect.com
Obesity is a metabolic disorder of increasing prevalence worldwide and a risk factor for the
development of insulin resistance (IR), metabolic syndrome and type 2 diabetes. Obesity is …

Adipocytokines in relation to cardiovascular disease

J Van de Voorde, B Pauwels, C Boydens, K Decaluwé - Metabolism, 2013 - Elsevier
Adipose tissue can be considered as a huge gland producing paracrine and endocrine
hormones, the adipo (cyto) kines. There is growing evidence that these adipo (cyto) kines …