Leptin has received much attention since its cloning in 1994. Initially, leptin research
centered on satiety, energy balance and sympathetic activation. However, hyperleptinemia …

Human adipose tissue is partitioned into two large depots (subcutaneous and visceral), and
many small depots associated with internal organs, eg heart, blood vessels, major lymph …

The relationship between adiposity and metabolic health is well established. However, very
little is known about the fat depot, known as paracardial fat (pCF), located superior to and …

Anatomical organization, genes and metabolic pathways in white, beige and brown adipose
tissues are traced from their invertebrate origins through lower vertebrates to mammals and …

Occlusion of a coronary artery if maintained for longer period of time results in damage of the
cardiac tissue. However, restoration of blood flow to previously ischemic tissue can itself …

Background Discrepancies are present in the literature on resting myocardial mechanics in
patients with uncomplicated type 2 diabetes mellitus (T2DM). Data are noticeably sparse …

Background Many cardiovascular diseases are closely related to the composition of
epicardial adipose tissue (EAT). Accurate segmentation of EAT can provide a reliable …

Mounting evidence has established a role for chronic inflammation in the development of
obesity-induced insulin resistance, as genetic ablation of pro-inflammatory cytokines and …

Abstract Background Metabolic syndrome (MetS) is associated with increased risk of
cardiovascular disease (CVD). One important feature underlying the pathophysiology of …

Cardiovascular disease is the primary cause of death in obese and diabetic patients. In
these groups of patients, the alterations of epicardial adipose tissue (EAT) contribute to both …