Plant-based compounds have been in the spotlight in search of new and promising drugs.
Flavokawain A, B and C are naturally occurring chalcones that have been isolated from …

Flavokawain B (FKB), a natural kava chalcone, displays potent antitumor activity in various
types of cancer. The mechanism of action, however, remains unclear. Here, we evaluated …

Kava (Piper methysticum Forst) is a popular and favorable edible medicinal herb which was
traditionally used to prepare a nonfermented beverage with relaxant beneficial for both …

Background Osteosarcoma (OS) is the most common primary bone malignancy with a high
propensity for local invasion and distant metastasis. Limited by the severe toxicity of …

Induction of apoptosis in tumor cells has become the major focus of anti-tumor therapeutics
development. Juglone, a major chemical constituent of Juglans mandshurica Maxim …

This study was designed to observe the treatment effects of flavokawain B (FKB) on gastric
cancer both in SGC‐7901 cells and nude mice. When SGC‐7901 cells were exposed to 10 …

Objective Herein, inhibition of hepatocyte growth factor receptor, c-Met, significantly
increased cytochrome c release and Bax/Bcl-2 ratio, indicating that c-Met played an anti …

Flavokawain B (FKB) possesses strong anti-neoplastic activity against many cancer cells.
Here we assessed its antitumor activity and molecular mechanisms in lung cancer H460 …

Piper, Capsicum, and Pimenta are the main genera of peppers consumed worldwide. The
traditional use of peppers by either ancient civilizations or modern societies has raised …

Background Kava is a beverage made from the ground roots of the plant Piper Methysticum
and has long‐held a significant place within Pacific island communities. Active compounds …