Depression is a common problem in patients with cardiovascular disease (CVD) and is
associated with increased mortality, excess disability, greater health care expenditures, and …

Importance Combining antidepressants is frequently done in the treatment of acute
depression, but studies have yielded conflicting results. Objective To conduct a systematic …

Background The effectiveness of the COVID-19 vaccination programme depends on mass
participation: the greater the number of people vaccinated, the less risk to the population …

Treatment‐resistant depression (TRD) is common and associated with multiple serious
public health implications. A consensus definition of TRD with demonstrated predictive utility …

Background The benefits and risks of augmenting or switching antidepressants in older
adults with treatment-resistant depression have not been extensively studied. Methods We …

Over a third of patients with major depressive disorder (MDD) do not have an adequate
response to first-line antidepressant treatments, ie, they have treatment-resistant depression …

Importance Treatment-resistant major depression (TRMD) in veterans is a major clinical
challenge given the high risk for suicidality in these patients. Repetitive transcranial …

Background: Major depressive disorder (MDD) is a highly burdensome health condition, for
which there are numerous accepted pharmacological and psychological interventions …

One in three adults with major depressive disorder (MDD) do not experience clinically
significant improvement after multiple sequential courses of antidepressants and have …

Depression is common in older adults and those with cardiovascular disease. Although
selective serotonin reuptake inhibitors generally have been shown to be safe to treat …