Treatment resistant depression (TRD) is associated with poor outcomes, but a consensus is
lacking in the literature regarding which compound represents the best pharmacological …

The Committee for Treatment Guidelines of Mood Disorders, Japanese Society of Mood
Disorders, published a Japanese guideline for the treatment of late‐life depression in 2020 …

Objective: The purpose of this study was to investigate the efficacy of cariprazine, a
dopamine D3-preferring D3/D2 and serotonin 5-HT1A receptor partial agonist, as adjunctive …

Background Although antidepressants are often a first‐line treatment for adults with
moderate to severe depression, many people do not respond adequately to medication, and …

The results of several meta-analyses suggest that eicosapentaenoic acid (EPA)
supplementation is therapeutic in managing the symptoms of major depression. It was …

The prediction of antidepressant response is critical for psychiatrists to select the initial
antidepressant drug for patients with major depressive disorders (MDD). The implicated …

Background For patients starting treatment for depression, current guidelines recommend
titrating the antidepressant dosage to the maximum of the licenced range if tolerated. When …

Background Depression and obesity are common health problems with major public health
implications. These conditions frequently co-occur, adversely affecting the course of the …

This evidence-based peer-reviewed eReport was prepared by Healthcare Global Village,
Inc. Financial support for preparation and dissemination of this eReport was provided by …

Further research is needed to help improve both the standard of care and the outcome for
patients with treatment-resistant depression. A particularly critical evidence gap exists with …