Objective Investigate incidence, risk factors and courses of treatment for treatment-resistant
depression (TRD) in primary and special healthcare. Methods All patients identified from …

Objective Evidence from clinical trials comparing effectiveness and safety of
pharmacological strategies in older adults unresponsive to first-line antidepressants is …

Objectives To evaluate the efficacy and safety of using adjunctive antipsychotics in patients
with major depressive disorder. Method Studies published since the last Cochrane review …

Depressed patients and their physicians naturally expect that each new antidepressant that
reaches the market will represent a conceptual and therapeutic advance over previous …

Objective Examine how specific types of childhood adversity are associated with clinical
features and treatment in adults with Major Depressive Disorder (MDD). Method This is a …

Objectives: Both psychiatric polypharmacy and multimorbidity are common in depressed
adults. We examine recent patterns of psychotropic polypharmacy with attention to …

Perinatal depression, defined as depressive symptoms occurring either during pregnancy
(antenatal depression [AND]) or postpartum (postpartum depression [PPD]) 1, 2 is …

Individuals in remission from depression (MDDR) tend to experience lingering cognitive and
emotional processing alterations. However, little is known about the neural profiles …

Selective serotonin reuptake inhibitors (SSRI) have been claimed to negatively affect the
thyroid function, albeit the evidence is controversial. We searched for studies that measured …

Abstract Background Randomised controlled trials (RCTs) aim to estimate the causal effect
of one or more interventions relative to a control. One type of outcome that can be of interest …