Major depressive disorder (MDD) is an often chronic and/or recurrent disorder that is
associated with dysfunctions in multiple aspects of life including work and non-workrelated …

Objective: Almost two-thirds of patients with major depressive disorder do not achieve
remission with initial treatments. Thus, identifying and providing effective, feasible, and safe …

Background Standard guidelines recommend selective serotonin reuptake inhibitors as first-
line antidepressants for adults with major depressive disorder, but success is limited and …

Objective: A recent moderately long-term study found an antipsychotic to be more effective
than an antidepressant as the next-step treatment of unresponsive major depressive …

Objective: To determine the proportion of adults treated for depression in the US who
achieve remission and, among those not achieving remission, the proportion receiving …

BackgroundIndividuals with treatment-resistant depression (TRD) experience a high burden
of illness. Current guidelines recommend a stepped care approach for treating depression …

Aim The stigma of mental disorders and poor treatment compliance can deprive patients
with major depressive disorder (MDD) of receiving standard treatment. This study aimed to …

Despite many advances in pharmacotherapy over the past half centurye, only a fraction of
patients with Major Depressive Disorder (MDD) can achieve remission after the first or …

Background The possibility of atypical antipsychotics (AA) to induce manic symptoms has
been raised by several articles. The objective of this study was to describe whether …

Importance Randomized controlled trials have demonstrated increased all-cause mortality in
elderly patients with dementia treated with newer antipsychotics. It is unknown whether this …