Guidance about treatment-resistant depression (TRD) in Portugal is very limited, even
though depression prevalence is among the highest in European countries. A questionnaire …

Depression is a heterogeneous disorder with a wide range of presentations. Most patients
with depression are seen in primary care, where it is often unrecognized; thus, screening for …

Background Using other central nervous system (CNS) medications in combination with
selective serotonin reuptake inhibitor (SSRI) treatment is common. Despite this, there is …

TMP269, a class IIA histone deacetylase inhibitor with selectivity, that has a protective effect
on the central nervous system, yet its specific mechanism of action remains ambiguous …

Introduction: Treatment-resistant depression (TRD) is a complex, multifactorial, and
biologically heterogeneous disorder with debilitating outcomes. Understanding individual …

Objective A better understanding of the biobehavioral mechanisms underlying depression in
cancer is required to translate biomarker findings into clinical interventions. We tested for …

Introduction Among treatment-resistant depression (TRD), we identified anergic-anhedonic
clinical presentations (TRAD) as putatively responsive to pro-dopaminergic strategies …

TO THE EDITOR: I am writing in reference to the article by Roger McIntyre et al.(1) on
ketamine. The article is generally well done, but I write to voice some reservations. For one …

BackgroundMajor depressive disorder (MDD) contributes to suicide risk. Treating MDD
effectively is considered a key suicide prevention intervention. Yet many patients with MDD …

M any patients with depression also experience anxiety symptoms. For some, these
symptoms reflect a coexisting, ongoing anxiety disorder, while for others, a significant surge …