Several extrinsic signals such as LIF, BMP and Wnt can support the self-renewal and
pluripotency of embryonic stem (ES) cells through regulating the “pluripotent genes.” A …

The Oct4 protein, encoded by the Pou5f1 gene was the very first master gene, discovered 25
years ago, to be absolutely required for the stemness properties of murine and primate …

Mammalian embryogenesis is characterized by rapid cellular proliferation and
diversification. Within a few weeks, a single-cell zygote gives rise to millions of cells …

The incorporation of histone H3 variants has been implicated in the epigenetic memory of
cellular state. Using genome editing with zinc-finger nucleases to tag endogenous H3. 3, we …

Stem cells capable of differentiating to multiple lineages may be valuable for therapy. We
report the isolation of human and rodent amniotic fluid–derived stem (AFS) cells that express …

Glioblastomas are lethal cancers characterized by florid angiogenesis promoted in part by
glioma stem cells (GSCs). Because hypoxia regulates angiogenesis, we examined hypoxic …

The molecular mechanisms underlying pluripotency and lineage specification from
embryonic stem cells (ESCs) are largely unclear. Differentiation pathways may be …

Much of the variation in inherited risk of colorectal cancer (CRC) is probably due to
combinations of common low risk variants. We conducted a genome-wide association study …

Pluripotency, a characteristic of cells in the inner cell mass of the mammalian
preimplantation blastocyst as well as of embryonic stem cells, is defined as the ability of a …

Billions of cells undergo apoptosis every day in the human body, resulting in the generation
of a large number of apoptotic vesicles (apoVs) to maintain organ and tissue homeostasis …