BACKGROUND Advanced maternal age is associated with decreased oocyte quantity and
quality as well as uterine and placental dysfunctions. These changes lead to infertility …

BACKGROUND Regulated cell death is a fundamental component of numerous
physiological processes; spanning from organogenesis in utero, to normal cell turnover …

Loss of fertility is a major concern for female reproductive-age cancer survivors, since a
common side-effect of conventional cytotoxic cancer therapies is permanent damage to the …

The preservation of genome integrity in the mammalian female germline from primordial
follicle arrest to activation of growth to oocyte maturation is fundamental to ensure …

Cryopreservation of ovarian tissue to preserve the fertility of girls and young women at high
risk of sterility is now widely practiced. Pieces of cryopreserved ovarian cortex can be …

Inflammation is a hallmark of aging and is negatively affecting female fertility. In this study,
we evaluate the role of the NLRP3 inflammasome in ovarian aging and female fertility. Age …

Based on the inconsistent literature published thus far involving infertile patients, whether
intracytoplasmic sperm injection (ICSI) allows overcoming total fertilization failure due to …

Objective To study the impact of sperm DNA fragmentation (SDF) on clinical outcomes of
assisted reproductive technology in women with different age ranges. Design Historical …

The fundamental underlying paradigm of sexual reproduction is the production of male and
female gametes of sufficient genetic difference and quality that, following syngamy, they …

STUDY QUESTION Does female ageing have a negative effect on the DNA repair capacity
of oocytes fertilised by spermatozoa with controlled levels of DNA damage? SUMMARY …