Molecular oxygen (O2) is essential for most biological reactions in mammalian cells. When
the intracellular oxygen content decreases, it is called hypoxia. The process of hypoxia is …

Cardiovascular diseases are the leading cause of death worldwide. During the development
of cardiovascular diseases, hypoxia plays a crucial role. Hypoxia-inducible factors (HIFs) are …

Oxygen, which is necessary for sustaining energy metabolism, is consumed in many
biochemical reactions in eukaryotes. When the oxygen supply is insufficient for maintaining …

Diabetes is a group of chronic diseases with blood glucose imbalance, and long-term
hyperglycaemia causes sustained damage to various organs of the body, resulting in …

During aging and after traumatic injuries, cartilage and bone cells are exposed to various
pathophysiologic mediators, including reactive oxygen species (ROS), damage-associated …

Senescent cells persist and continuously secrete proinflammatory and tissue-remodeling
molecules that poison surrounding cells, leading to various age-related diseases, including …

Simple Summary The regulation of hypoxia has recently emerged as having a central impact
in mitochondrial function and dysfunction in various diseases, including the major disorders …

Obstructive sleep apnea (OSA) is a chronic condition characterized by recurrent pauses in
breathing caused by the collapse of the upper airways, which results in intermittent hypoxia …

Pulmonary hypertension (PH) is a chronic and fatal disease, for which new therapeutic
drugs and approaches are needed urgently. Baicalein and baicalin, the active compounds …

Parkinson's disease (PD) is the second most common neurodegenerative disease after
Alzheimer's disease, with typical motor symptoms as the main clinical manifestations. At …