The therapeutic properties of plants have been recognised since time immemorial. Many
pathological conditions have been treated using plant-derived medicines. These medicines …

Emerging threats to human health require a concerted effort in search of both preventive and
treatment strategies, placing natural products at the center of efforts to obtain new therapies …

Inferring the structure and dynamics of network models is critical to understanding the
functionality and control of complex systems, such as metabolic and regulatory biological …

The massive acquisition of data in molecular and cellular biology has led to the renaissance
of an old topic: simulations of biological systems. Simulations, increasingly paired with …

Liver transplantation is currently the only established treatment of end-stage liver disease,
but it is limited by a severe shortage of viable donor livers. Donors after cardiac death (DCD) …

An experimental set‐up for acquiring metabolite and transient 13C‐labeling data in
mammalian cells is presented. An efficient sampling procedure was established for hepatic …

This contribution addresses the identification of metabolic fluxes and metabolite
concentrations in mammalian cells from transient 13C‐labeling experiments. Whilst part I …

Flux balance analysis (FBA) provides a framework for the estimation of intracellular fluxes
and energy balance analysis (EBA) ensures the thermodynamic feasibility of the computed …

This review summarizes some of the recent developments and identifies critical challenges
associated with in vitro and in silico representations of the liver and assesses the …

Cellular systems are networks of interacting components that change with time in response
to external and internal events. Studying the dynamic behavior of these networks is the basis …