Introduction Several reports have shown marked heterogeneity of antibiotic
pharmacokinetics (PK) in patients admitted to ICUs, which might potentially affect outcomes …

Introduction: The pharmacokinetic/pharmacodynamic index determining β-lactam activity is
the percentage of the dosing interval (% T) during which their free serum concentration …

For four decades, physicians and other healthcare providers have trusted Mandell, Douglas,
and Bennett's Principles and Practice of Infectious Diseases to provide expert guidance on …

Cubre la epidemiología, la etiología, la patología, la microbiología, la inmunología y el
tratamiento de los agentes infecciosos en mayor profundidad que ninguna otra obra de la …

Objectives Emerging evidence supports the use of therapeutic drug monitoring (TDM) of β-
lactams for intensive care unit (ICU) patients to optimize drug exposure, although limited …

Introduction Therapeutic drug monitoring (TDM) has been recommended for treatment
optimization in tuberculosis (TB) but is only is used in certain countries eg USA, Germany …

There is controversy over whether traditional intermittent bolus dosing or continuous infusion
of beta-lactam antibiotics is preferable in critically ill patients. No significant difference …

Objective This overview of reviews aims to map and compare of objectives, methods, and
findings of existing systematic reviews to develop a greater understanding of the information …

Antimicrobial resistance is a national public health concern. Misuse of antimicrobials for
conditions such as upper respiratory infection, urinary tract infections, and cellulitis has led …

BACKGROUND: β-Lactam antibiotics demonstrate time-dependent killing. Prolonged
infusion of these agents is commonly performed to optimize the time the unbound …