The gastrointestinal tract develops from a simple and uniform tube into a complex organ with
specific differentiation patterns along the anterior–posterior and dorso-ventral axes of …

Introduction: Risk prediction of gastric cancers is important to implement appropriate
screening procedures. Although aberrant DNA methylation is deeply involved in gastric …

Altered patterns of DNA methylation associated with Helicobacter pylori (HP) infection of
gastric epithelial cells are thought to contribute to gastric cancer risk. However, it is unclear …

The gastric mucosal immune system is a unique immune organ independent of systemic
immunity that not only maintains nutrient absorption but also plays a role in resisting the …

Objective Alternatively activated macrophages (M2) are associated with the progression of
spasmolytic polypeptide-expressing metaplasia (SPEM) in the stomach. However, the …

Suppression of aberrant DNA methylation is a novel approach to cancer prevention, but, so
far, the efficacy of the strategy has not been evaluated in cancers associated with chronic …

The conservative nature of animal evolution makes animal models the ideal tool for learning
about human biology. The Handbook of Laboratory Animal Science, Second Edition: Animal …

The discovery of Helicobacter pylori (Hp) infection of gastric mucosa leading to active
chronic gastritis, gastroduodenal ulcers, and MALT lymphoma laid the groundwork for …

Spasmolytic polypeptide‐expressing metaplasia (SPEM) and intestinal metaplasia are
considered neoplastic precursors of gastric adenocarcinoma in humans. Loss of parietal …

Background The secular trend in the prevalence of Helicobacter pylori (H. pylori) infection
among children and adolescents in Japan has not been well documented. Materials and …