Epidemiology of chronic myeloid leukaemia (CML)

M Rohrbacher, J Hasford - Best practice & research Clinical haematology, 2009 - Elsevier
Reliable epidemiological information on chronic myeloproliferative disorders (CMPDs),
notably Philadelphia (Ph)/BCR-ABL-positive chronic myeloid leukaemia (CML), is rare …

Resistance to tyrosine kinase inhibition therapy for chronic myelogenous leukemia: a clinical perspective and emerging treatment options

EJ Jabbour, JE Cortes, HM Kantarjian - Clinical Lymphoma Myeloma and …, 2013 - Elsevier
The development of tyrosine kinase inhibitors (TKIs) has led to extended lifespans for many
patients with chronic myelogenous leukemia (CML). However, 20% to 30% of patients fail to …

Molecular monitoring in chronic myeloid leukemia: response to tyrosine kinase inhibitors and prognostic implications

E Jabbour, JE Cortes, HM Kantarjian - Cancer, 2008 - Wiley Online Library
The majority of patients with chronic‐phase (CP) chronic myeloid leukemia (CML) who are
treated with Bcr‐Abl tyrosine kinase inhibitors such as imatinib and dasatinib achieve …

First‐line treatment selection and early monitoring patterns in chronic phase‐chronic myeloid leukemia in routine clinical practice: SIMPLICITY

SL Goldberg, JE Cortes… - American journal of …, 2017 - Wiley Online Library
Achieving successful outcomes in chronic phase‐chronic myeloid leukemia (CP‐CML)
requires careful monitoring of cytogenetic/molecular responses (CyR/MR). SIMPLICITY …

Suboptimal response to or failure of imatinib treatment for chronic myeloid leukemia: what is the optimal strategy?

E Jabbour, JE Cortes, HM Kantarjian - Mayo Clinic Proceedings, 2009 - Elsevier
Treatment responses to imatinib vary among patients with chronic myeloid leukemia (CML),
and definitions of treatment failure and suboptimal response have been published. This …

Conditional survival in patients with chronic myeloid leukemia in chronic phase in the era of tyrosine kinase inhibitors

K Sasaki, HM Kantarjian, P Jain, EJ Jabbour… - Cancer, 2016 - Wiley Online Library
BACKGROUND Tyrosine kinase inhibitors (TKIs) significantly improve survival in patients
with chronic myeloid leukemia in chronic phase (CML‐CP). Conditional probability provides …

Chronic myeloid leukemia in the Asia-Pacific region: current practice, challenges and opportunities in the targeted therapy era

DW Kim, SD Banavali, U Bunworasate, YT Goh… - Leukemia research, 2010 - Elsevier
Chronic myeloid leukemia (CML) management varies across Asia due to disparities in
affluence and healthcare provision. We surveyed CML management practice at 33 hospitals …

Current patient management of chronic myeloid leukemia in Latin America: a study by the Latin American Leukemia Net (LALNET)

J Cortes, C De Souza, M Ayala‐Sanchez, I Bendit… - Cancer, 2010 - Wiley Online Library
BACKGROUND: Treatment recommendations have been developed for management of
patients with chronic myeloid leukemia (CML). METHODS: A 30‐item multiple‐choice …

Molecular diagnosis and monitoring in the clinical management of patients with chronic myelogenous leukemia treated with tyrosine kinase inhibitors

J Ou, JA Vergilio, A Bagg - American journal of hematology, 2008 - Wiley Online Library
The well‐established molecular pathogenesis of chronic myelogenous leukemia (CML) and
its consequences for laboratory testing and clinical management illustrate a classic …

Evaluation of resistance to HIV-1 infection ex vivo of PBMCs isolated from patients with chronic myeloid leukemia treated with different tyrosine kinase inhibitors

M Bermejo, J Ambrosioni, G Bautista, N Climent… - Biochemical …, 2018 - Elsevier
Current antiretroviral treatment (ART) may control HIV-1 replication but it cannot cure the
infection due to the formation of a reservoir of latently infected cells. CD4+ T cell activation …