An excess of saturated fatty acids and simple sugars in the diet is a known environmental
risk factor of Alzheimer's disease (AD) but the holistic view of the interacting processes …

Early reviews identified over 20 risk factors associated with Alzheimer's disease (AD)
including age, familial inheritance, exposure to aluminium, traumatic brain injury (TBI), and …

Aging is the greatest risk factor for most diseases including cancer, cardiovascular disorders,
and neurodegenerative disease. There is emerging evidence that interventions that improve …

Despite intensive research efforts over the past few decades, the mechanisms underlying
the etiology of sporadic Alzheimer's disease (AD) remain unknown. This fact is of major …

Abstract Background Approximately 70% of Alzheimer's disease (AD) patients have co-
morbid vascular contributions to cognitive impairment and dementia (VCID); this highly …

Dementia prevalence increases with age and Alzheimer's disease (AD) accounts for up to
75% of cases. However, significant variability and overlap exists in the extent of amyloid-β …

Central response to insulin is suspected to be defective in Alzheimer's disease. As most
insulin is secreted in the bloodstream by the pancreas, its capacity to regulate brain …

Background Obesity rates are increasing worldwide. Obesity leads to many complications,
including predisposing individuals to the development of cognitive impairment as they age …

High-fat diet (HFD) has been applied to a variety of inbred mouse strains to induce obesity
and obesity related metabolic complications. In this study, we determined HFD induced …

Obesity, metabolic syndrome, and type 2 diabetes (T2D) are related disorders with
widespread deleterious effects throughout the body. One important target of damage is the …