Scale-up of pharmaceutical spray drying using scale-up rules: A review
Spray drying is one of the widely used manufacturing processes in pharmaceutical industry.
While there are voluminous experimental studies pertaining to the impact of various process …
While there are voluminous experimental studies pertaining to the impact of various process …
Cellulose-based dispersants and flocculants
R Koshani, M Tavakolian… - Journal of Materials …, 2020 - pubs.rsc.org
Natural dispersants and flocculants, often referred to as dispersion stabilizers and liquid–
solid separators, respectively, have secured a promising role in the bioprocessing …
solid separators, respectively, have secured a promising role in the bioprocessing …
Impact of biopolymer-surfactant interactions on the particle aggregation inhibition of β-carotene in high loaded microcapsules: Spontaneous dispersibility and in vitro …
The particle aggregation of β-carotene has been a challenge for the development of
powdery microcapsules with a high loading. Herein, solvent-free β-carotene high loaded …
powdery microcapsules with a high loading. Herein, solvent-free β-carotene high loaded …
Spray drying as an advantageous strategy for enhancing pharmaceuticals bioavailability
AH Salama - Drug Delivery and Translational Research, 2020 - Springer
Spray drying is an efficient technique that is used not only for rapid evaporation of the
solvent from different systems but also for designing ultra-fine particles with various …
solvent from different systems but also for designing ultra-fine particles with various …
Mechanistic modeling of wet stirred media milling for production of drug nanosuspensions
Drug nanocrystals have been used for a wide range of drug delivery platforms in the
pharmaceutical industry, especially for bioavailability enhancement of poorly water-soluble …
pharmaceutical industry, especially for bioavailability enhancement of poorly water-soluble …
[HTML][HTML] Optimization of curcumin nanocrystals as promising strategy for nose-to-brain delivery application
A Bonaccorso, MR Gigliobianco, R Pellitteri… - Pharmaceutics, 2020 - mdpi.com
Intranasal (IN) drug delivery is recognized to be an innovative strategy to deliver drugs to the
Central Nervous System. One of the main limitations of IN dosing is the low volume of drug …
Central Nervous System. One of the main limitations of IN dosing is the low volume of drug …
[HTML][HTML] Itraconazole nanosuspensions via dual centrifugation media milling: Impact of formulation and process parameters on particle size and solid-state conversion …
AC Willmann, K Berkenfeld, T Faber, H Wachtel… - Pharmaceutics, 2022 - mdpi.com
Nanocrystal suspensions proved to be a potent enabling principle for biopharmaceutics
classification system class II drugs with dissolution limited bioavailability. In the example of …
classification system class II drugs with dissolution limited bioavailability. In the example of …
Hybrid nanocrystal–amorphous solid dispersions (HyNASDs) as alternative to ASDs for enhanced release of BCS Class II drugs
A major shortcoming of drug nanocomposites as compared with amorphous solid
dispersions (ASDs) is their limited supersaturation capability in dissolution media. Here, we …
dispersions (ASDs) is their limited supersaturation capability in dissolution media. Here, we …
Roles of surfactant and polymer in drug release from spray-dried hybrid nanocrystal-amorphous solid dispersions (HyNASDs)
We prepared hybrid nanocrystal–amorphous solid dispersions (HyNASDs) to enhance the
dissolution of a poorly soluble drug, griseofulvin (GF), and elucidated the roles of a …
dissolution of a poorly soluble drug, griseofulvin (GF), and elucidated the roles of a …
[HTML][HTML] Spray-dried amorphous solid dispersions of griseofulvin in HPC/soluplus/SDS: Elucidating the multifaceted impact of SDS as a minor component
This study aimed to elucidate the impact of a common anionic surfactant, sodium dodecyl
sulfate (SDS), along with hydroxypropyl cellulose (HPC) and Soluplus (Sol) on the release …
sulfate (SDS), along with hydroxypropyl cellulose (HPC) and Soluplus (Sol) on the release …