The state of clinical art of the coagulopathy of cirrhosis changed considerably over the last
decade. Until 2005, cirrhosis was considered as the epitome of the hemorrhagic …

Patients with chronic or acute liver failure frequently show profound abnormalities in their
hemostatic system. Whereas routine laboratory tests of hemostasis suggest these …

Elevated plasma clot lysis time (CLT) increases risk of venous and arterial thrombosis. It is
unclear which fibrinolytic factors contribute to thrombosis risk. In 743 healthy control subjects …

Normal coagulation has classically been conceptualized as a Y‐shaped pathway, with
distinct “intrinsic” and “extrinsic” components initiated by factor XII or factor VIIa/tissue factor …

Decreased levels of most coagulation factors and thrombocytopenia are the main
haemostatic abnormalities of cirrhosis. As a consequence, this condition was, until recently …

Background and Aims Recent evidence suggests that acute kidney injury (AKI) is the main
predictor of postparacentesis bleeding in patients with cirrhosis. To assess the factors …

A beneficial effect of recombinant activated factor VII (rFVIIa) in Child‐Pugh class B and C
patients with cirrhosis who have variceal bleeding has been suggested. This randomized …

Liver disease results in complex alterations of all 3 phases of hemostasis. It is now
recognized that hemostasis is rebalanced in chronic liver disease. The fall in clotting factor …

Essentials• Patients with liver diseases may acquire substantial changes in all components
of hemostasis.• Hemostasis is in unstable balance due to simultaneous changes in pro‐and …

The role of the fibrinolytic system in the development of deep vein thrombosis (DVT) is
unclear. We determined the plasma fibrinolytic potential of patients enrolled in the Leiden …