Liver disease impacts on both primary and secondary haemostatic mechanisms and
historically these changes were thought to underpin the bleeding diathesis. However …

The hemostatic balance in patients with liver diseases is relatively well preserved due to
concomitant alterations in pro-and antihemostatic pathways. Thrombin generation studies …

Background and Aims Patients with advanced liver cirrhosis have an increased
susceptibility to infections. As part of the cirrhosis‐associated immune dysfunction, mucosal …

Nanotechnology has evolved as a novel multidisciplinary concept of the twenty-first century,
abridging gaps in materials science, engineering, life sciences and medicine, with …

It has been well established that inherited or acquired hypercoagulability is a risk factor for
venous thrombosis. In addition, hypercoagulability may contribute to the risk of arterial …

The incidence of hyperfibrinolysis in patients with cirrhosis is still debated. The reasons for
this uncertainty probably lie in the lack of appropriate laboratory tests for its evaluation …

Apart from the well‐known role of blood platelets in hemostasis, there is emerging evidence
that platelets have various nonhemostatic properties that play a critical role in inflammation …

Background The coagulopathy in cirrhosis is associated with thrombosis and bleeding.
Objectives To gain better insights into the coagulopathy in patients with cirrhosis, we …

The complex nature of haemostasis in patients with liver disease can result in bleeding
and/or thrombosis. These opposing outcomes, which have multiple contributing factors, can …

Adequate plasma levels of fibrinogen are essential for clot formation, and in severe
bleeding, fibrinogen reaches a critically low plasma concentration earlier than other …