In February and March 1978 I delivered my first series of Gifford Lectures in the University of
Edinburgh. These lectures have been published under the title The Human Mystery. The …

Although 5-HT is clearly involved in spinal analgesia, its mode of action remains obscure,
perhaps because it has multiple and often opposing effects mediated by its multiple receptor …

The opioid analgesics, commonly exemplified by morphine, represent the best option for the
treatment of severe pain and for the management of chronic pain states, of both malignant …

Much progress has been made the understanding of endogenous pain controlling systems.
Recently, new concepts and ideas which are derived from neurobiology, chaos research …

The effects of peppermint oil and eucalyptus oil preparations on neurophysiological,
psychological and experimental algesimetric parameters were investigated in 32 healthy …

In previous studies, we have shown that loss of spinal neurons that possess the substance P
receptor (SPR) attenuated pain and hyperalgesia produced by capsaicin, inflammation, and …

Although the opioids are the principal treatment options for moderate to severe pain, their
use is also associated with the development of tolerance, defined as the progressive need …

Opioid-based narcotics are the most widely prescribed therapeutic agent for the alleviation
of persistent pain; however, it is becoming increasingly clear that morphine is significantly …

Extensive evidence has indicated that distinct neural systems specifically designed to inhibit
sensitivity to painful stimuli exist. Recent advances suggest that the endorphins, enkephalins …

Reports a series of experiments in rats, demonstrating that (a) inhibition of spinal function by
periaqueductal gray (PAG) morphine associated with antinociception is mediated by the …