Physiology of astroglia

A Verkhratsky, M Nedergaard - Physiological reviews, 2018 - journals.physiology.org
Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …

[HTML][HTML] Design principles of insect and vertebrate visual systems

JR Sanes, SL Zipursky - Neuron, 2010 - cell.com
A century ago, Cajal noted striking similarities between the neural circuits that underlie
vision in vertebrates and flies. Over the past few decades, structural and functional studies …

[HTML][HTML] A connectome and analysis of the adult Drosophila central brain

LK Scheffer, CS Xu, M Januszewski, Z Lu, S Takemura… - elife, 2020 - elifesciences.org
The neural circuits responsible for animal behavior remain largely unknown. We summarize
new methods and present the circuitry of a large fraction of the brain of the fruit fly …

[HTML][HTML] A complete electron microscopy volume of the brain of adult Drosophila melanogaster

Z Zheng, JS Lauritzen, E Perlman, CG Robinson… - Cell, 2018 - cell.com
Drosophila melanogaster has a rich repertoire of innate and learned behaviors. Its 100,000-
neuron brain is a large but tractable target for comprehensive neural circuit mapping. Only …

Optimized tools for multicolor stochastic labeling reveal diverse stereotyped cell arrangements in the fly visual system

A Nern, BD Pfeiffer, GM Rubin - Proceedings of the …, 2015 - National Acad Sciences
We describe the development and application of methods for high-throughput
neuroanatomy in Drosophila using light microscopy. These tools enable efficient multicolor …

[HTML][HTML] Complete connectomic reconstruction of olfactory projection neurons in the fly brain

AS Bates, P Schlegel, RJV Roberts, N Drummond… - Current Biology, 2020 - cell.com
Nervous systems contain sensory neurons, local neurons, projection neurons, and motor
neurons. To understand how these building blocks form whole circuits, we must distil these …

[HTML][HTML] A genetic, genomic, and computational resource for exploring neural circuit function

FP Davis, A Nern, S Picard, MB Reiser, GM Rubin… - Elife, 2020 - elifesciences.org
The anatomy of many neural circuits is being characterized with increasing resolution, but
their molecular properties remain mostly unknown. Here, we characterize gene expression …

The glia of the adult Drosophila nervous system

MC Kremer, C Jung, S Batelli, GM Rubin, U Gaul - Glia, 2017 - Wiley Online Library
Glia play crucial roles in the development and homeostasis of the nervous system. While the
GLIA in the Drosophila embryo have been well characterized, their study in the adult …

[HTML][HTML] Quantitative neuroanatomy for connectomics in Drosophila

CM Schneider-Mizell, S Gerhard, M Longair… - Elife, 2016 - elifesciences.org
Neuronal circuit mapping using electron microscopy demands laborious proofreading or
reconciliation of multiple independent reconstructions. Here, we describe new methods to …

Stratification of astrocytes in healthy and diseased brain

A Verkhratsky, R Zorec, V Parpura - Brain Pathology, 2017 - Wiley Online Library
Astrocytes, a subtype of glial cells, come in variety of forms and functions. However,
overarching role of these cell is in the homeostasis of the brain, be that regulation of ions …