Cognitive impairment in multiple sclerosis: clinical management, MRI, and therapeutic avenues

RHB Benedict, MP Amato, J DeLuca… - The Lancet …, 2020 - thelancet.com
Multiple sclerosis is a chronic, demyelinating disease of the CNS. Cognitive impairment is a
sometimes neglected, yet common, sign and symptom with a profound effect on instrumental …

Recommendations for cognitive screening and management in multiple sclerosis care

R Kalb, M Beier, RHB Benedict… - Multiple Sclerosis …, 2018 - journals.sagepub.com
Purpose: To promote understanding of cognitive impairment in multiple sclerosis (MS),
recommend optimal screening, monitoring, and treatment strategies, and address barriers to …

[HTML][HTML] Depressive symptoms, anxiety and cognitive impairment: emerging evidence in multiple sclerosis

M Margoni, P Preziosa, MA Rocca, M Filippi - Translational Psychiatry, 2023 - nature.com
Neuropsychiatric abnormalities may be broadly divided in two categories: disorders of
mood, affect, and behavior and abnormalities affecting cognition. Among these conditions …

Siponimod and cognition in secondary progressive multiple sclerosis: EXPAND secondary analyses

RHB Benedict, D Tomic, BA Cree, R Fox… - Neurology, 2021 - AAN Enterprises
Objective To investigate the effects of siponimod on cognitive processing speed in patients
with secondary progressive (SP) multiple sclerosis (MS), by means of a predefined …

Computerized cognitive training in multiple sclerosis: a systematic review and meta-analysis

A Lampit, J Heine, C Finke, MH Barnett… - … and Neural Repair, 2019 - journals.sagepub.com
Background. Cognitive impairments are common in people with multiple sclerosis (MS).
Systematic reviews reported promising evidence for various cognitive interventions in this …

[HTML][HTML] Cognitive dysfunction in the early stages of multiple sclerosis—how much and how important?

M Oset, M Stasiolek, M Matysiak - Current neurology and neuroscience …, 2020 - Springer
Abstract Purpose of Review Multiple sclerosis (MS) is a demyelinating disease of the central
nervous system that mainly affects young adults and that is one of the leading causes of …

Molecular biomarkers and cognitive impairment in multiple sclerosis: state of the field, limitations, and future direction–a systematic review and meta-analysis

TD Rademacher, SG Meuth, H Wiendl, A Johnen… - Neuroscience & …, 2023 - Elsevier
Objective Multiple sclerosis (MS) is associated with cognitive impairment (CI) such as
slowed information processing speed (IPS). Currently, no immunocellular or molecular …

Prediction of the information processing speed performance in multiple sclerosis using a machine learning approach in a large multicenter magnetic resonance …

C Marzi, A d'Ambrosio, S Diciotti, A Bisecco… - Human Brain …, 2023 - Wiley Online Library
Many patients with multiple sclerosis (MS) experience information processing speed (IPS)
deficits, and the Symbol Digit Modalities Test (SDMT) has been recommended as a valid …

[HTML][HTML] The blood concentration of metallic nanoparticles is related to cognitive performance in people with multiple sclerosis: An exploratory analysis

M de Oliveira, FB Santinelli, PN Lisboa-Filho… - Biomedicines, 2023 - mdpi.com
The imbalance in the concentration of metallic nanoparticles has been demonstrated to play
an important role in multiple sclerosis (MS), which may impact cognition. Biomarkers are …

A systematic review of resting-state functional MRI connectivity changes and cognitive impairment in multiple sclerosis

D Jandric, A Doshi, R Scott, D Paling, D Rog… - Brain …, 2022 - liebertpub.com
Introduction: Cognitive impairment in multiple sclerosis (MS) is increasingly being
investigated with resting-state functional MRI (rs-fMRI) functional connectivity (FC). However …