Molecular mechanisms of the cardiovascular protective effects of polyphenols

R Andriantsitohaina, C Auger, T Chataigneau… - British Journal of …, 2012 - cambridge.org
Epidemiological studies have reported a greater reduction in cardiovascular risk and
metabolic disorders associated with diets rich in polyphenols. The antioxidant effects of …

Chemistry and pharmacological actions of delphinidin, a dietary purple pigment in anthocyanidin and anthocyanin forms

A Husain, H Chanana, SA Khan… - Frontiers in …, 2022 - frontiersin.org
Anthocyanins are naturally occurring water-soluble flavonoids abundantly present in fruits
and vegetables. They are polymethoxyderivatives of 2-phenyl-benzopyrylium or flavylium …

Ferulic acid attenuates liver fibrosis and hepatic stellate cell activation via inhibition of TGF-β/Smad signaling pathway

M Mu, S Zuo, RM Wu, KS Deng, S Lu… - Drug design …, 2018 - Taylor & Francis
Purpose Liver fibrosis is a worldwide health issue. Development of effective new drugs for
treatment of this disease is of great importance. This study investigated the therapeutic …

Myricitrin exhibits antioxidant, anti-inflammatory and antifibrotic activity in carbon tetrachloride-intoxicated mice

R Domitrović, K Rashed, O Cvijanović… - Chemico-biological …, 2015 - Elsevier
Abstract Myricetin-3-O-α-rhamnoside (myricitrin) is a naturally occurring phenolic compound
which possesses antioxidant and anti-inflammatory activity. The aim of this study was to …

Hepatoprotective activity of berberine is mediated by inhibition of TNF-α, COX-2, and iNOS expression in CCl4-intoxicated mice

R Domitrović, H Jakovac, G Blagojević - Toxicology, 2011 - Elsevier
This study investigated the protective effects of isoquinoline alkaloid berberine on the CCl4-
induced hepatotoxicity in mice. Berberine was administered as a single dose at 5 and …

Human diet‐derived polyphenolic compounds and hepatic diseases: From therapeutic mechanisms to clinical utilization

Q Hu, W Zhang, F Wei, M Huang, M Shu… - Phytotherapy …, 2024 - Wiley Online Library
This review focuses on the potential ameliorative effects of polyphenolic compounds derived
from human diet on hepatic diseases. It discusses the molecular mechanisms and recent …

Differential hepatoprotective mechanisms of rutin and quercetin in CCl4-intoxicated BALB/cN mice

R Domitrović, H Jakovac, V Vasiljev Marchesi… - Acta Pharmacologica …, 2012 - nature.com
Aim: To investigate the mechanisms underlying the protective effects of quercetin-rutinoside
(rutin) and its aglycone quercetin against CCl 4-induced liver damage in mice. Methods …

Rosmarinic acid ameliorates acute liver damage and fibrogenesis in carbon tetrachloride-intoxicated mice

R Domitrović, M Škoda, VV Marchesi… - Food and chemical …, 2013 - Elsevier
The aim of this study was to investigate the therapeutic potential of rosmarinic acid (RA), a
natural phenolic, in the treatment of acute liver toxicity. RA at 10, 25 and 50mg/kg was …

Flavonoids-mediated SIRT1 signaling activation in hepatic disorders

AM Sayed, EHM Hassanein, SH Salem, OE Hussein… - Life sciences, 2020 - Elsevier
The prevalence of various hepatic diseases increases dramatically worldwide and regarded
as a serious health problem. Sirtuins are one of the main strategic controllers of different …

[HTML][HTML] Evaluation of berberine efficacy in reducing the effects of aflatoxin B1 and ochratoxin A added to male broiler rations

P Malekinezhad, LE Ellestad, N Afzali, SH Farhangfar… - Poultry Science, 2021 - Elsevier
Many types of mycotoxins are found in food sources contaminated with fungi, and if these
are ingested in large quantities or over a long period, they can affect the health of humans …