RNA molecules are essential for cellular information transfer and gene regulation, and
RNAs have been implicated in many human diseases. Messenger and non-coding RNAs …

This review aims at juxtaposing common versus distinct structural and functional strategies
that are applied by aptamers, riboswitches, and ribozymes/DNAzymes. Focusing on recently …

RNA molecules adopt three-dimensional structures that are critical to their function and of
interest in drug discovery. Few RNA structures are known, however, and predicting them …

Abstract The HDOCK server (http://hdock. phys. hust. edu. cn/) is a highly integrated suite of
homology search, template-based modeling, structure prediction, macromolecular docking …

Cryo-electron microscopy (cryo-EM) has emerged as an unprecedented tool to resolve
protein structures at atomic resolution. Structural insights of biological samples not …

We describe an experimental method of three-dimensional (3D) structure determination that
exploits the increasing ease of high-throughput mutational scans. Inspired by the success of …

RNA-Puzzles is a collective endeavor dedicated to the advancement and improvement of
RNA 3D structure prediction. With agreement from crystallographers, the RNA structures are …

Hybrid RNA: DNA origami, in which a long RNA scaffold strand folds into a target
nanostructure via thermal annealing with complementary DNA oligos, has only been …

RNA is a unique bio-macromolecule that can both record genetic information and perform
biological functions in a variety of molecular processes, including transcription, splicing …

Long non-coding RNAs (lncRNAs) constitute a significant fraction of the transcriptome,
playing important roles in development and disease. However, our understanding of …