The role of HER2, EGFR, and other receptor tyrosine kinases in breast cancer
JL Hsu, MC Hung - Cancer and Metastasis Reviews, 2016 - Springer
Breast cancer affects approximately 1 in 8 women, and it is estimated that over 246,660
women in the USA will be diagnosed with breast cancer in 2016. Breast cancer mortality has …
women in the USA will be diagnosed with breast cancer in 2016. Breast cancer mortality has …
New strategies for fluorescent probe design in medical diagnostic imaging
H Kobayashi, M Ogawa, R Alford, PL Choyke… - Chemical …, 2010 - ACS Publications
In vivo medical imaging has made great progress due to advances in the engineering of
imaging devices and developments in the chemistry of imaging probes. Several modalities …
imaging devices and developments in the chemistry of imaging probes. Several modalities …
Pancancer survival analysis of cancer hallmark genes
Á Nagy, G Munkácsy, B Győrffy - Scientific reports, 2021 - nature.com
Cancer hallmark genes are responsible for the most essential phenotypic characteristics of
malignant transformation and progression. In this study, our aim was to estimate the …
malignant transformation and progression. In this study, our aim was to estimate the …
PI3K/Akt signalling pathway and cancer
JÁF Vara, E Casado, J de Castro, P Cejas… - Cancer treatment …, 2004 - Elsevier
Phosphatidylinositol-3 kinases, PI3Ks, constitute a lipid kinase family characterized by their
ability to phosphorylate inositol ring 3′-OH group in inositol phospholipids to generate the …
ability to phosphorylate inositol ring 3′-OH group in inositol phospholipids to generate the …
Oncogenic kinase signalling
P Blume-Jensen, T Hunter - Nature, 2001 - nature.com
Protein-tyrosine kinases (PTKs) are important regulators of intracellular signal-transduction
pathways mediating development and multicellular communication in metazoans. Their …
pathways mediating development and multicellular communication in metazoans. Their …
[HTML][HTML] Mechanism, safety and efficacy of three tyrosine kinase inhibitors lapatinib, neratinib and pyrotinib in HER2-positive breast cancer
JC Xuhong, XW Qi, Y Zhang, J Jiang - American journal of cancer …, 2019 - ncbi.nlm.nih.gov
The incidence of breast cancer ranks first among female malignant tumors that affect
women's health. Epidermal growth factor receptor (EGFR) family overexpression, especially …
women's health. Epidermal growth factor receptor (EGFR) family overexpression, especially …
Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab
HS Cho, K Mason, KX Ramyar, AM Stanley, SB Gabelli… - Nature, 2003 - nature.com
HER2 (also known as Neu, ErbB2) is a member of the epidermal growth factor receptor
(EGFR; also known as ErbB) family of receptor tyrosine kinases, which in humans includes …
(EGFR; also known as ErbB) family of receptor tyrosine kinases, which in humans includes …
The protein kinase B/Akt signalling pathway in human malignancy
KM Nicholson, NG Anderson - Cellular signalling, 2002 - Elsevier
Protein kinase B or Akt (PKB/Akt) is a serine/threonine kinase, which in mammals comprises
three highly homologous members known as PKBα (Akt1), PKBβ (Akt2), and PKBγ (Akt3) …
three highly homologous members known as PKBα (Akt1), PKBβ (Akt2), and PKBγ (Akt3) …
A structural perspective on the regulation of the epidermal growth factor receptor
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that plays a
critical role in the pathogenesis of many cancers. The structure of intact forms of this receptor …
critical role in the pathogenesis of many cancers. The structure of intact forms of this receptor …
Targeting HER2 for the treatment of breast cancer
HER2 (ErbB2), a member of the HER family of tyrosine kinase receptors (HER1–4), is a
major driver of tumor growth in 20% of breast cancers. Treatment with the anti-HER2 …
major driver of tumor growth in 20% of breast cancers. Treatment with the anti-HER2 …