Vascular cognitive impairment and dementia (VCID) is commonly caused by vascular
injuries in cerebral large and small vessels and is a key driver of age-related cognitive …

Recent transcriptomic, histological and functional studies have begun to shine light on the
fibroblasts present in the meninges, choroid plexus and perivascular spaces of the brain and …

Despite the importance of the cerebrovasculature in maintaining normal brain physiology
and in understanding neurodegeneration and drug delivery to the central nervous system …

Leptomeninges, consisting of the pia mater and arachnoid, form a connective tissue
investment and barrier enclosure of the brain. The exact nature of leptomeningeal cells has …

Background: Preservation of brain health has emerged as a leading public health priority for
the aging world population. Advances in neurovascular biology have revealed an intricate …

The meninges are the fibrous covering of the central nervous system (CNS) which contain
vastly heterogeneous cell types within its three layers (dura, arachnoid, and pia). The dural …

Central nervous system (CNS) trauma activates a persistent repair response that leads to
fibrotic scar formation within the lesion. This scarring is similar to other organ fibrosis in …

Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system
(CNS) and the most common non-traumatic cause of neurological disability in young adults …

Investigations of memory mechanisms have been, thus far, neuron centric, despite the brain
comprising diverse cell types. Using rats and mice, we assessed the cell-type-specific …

Electron microscopy is the primary approach to study ultrastructural features of the
cerebrovasculature. However, 2D snapshots of a vascular bed capture only a small fraction …